黄曲霉毒素B1 - 2,3 - 环氧化物可能是黄曲霉毒素B1和B2在体内与大鼠肝脏DNA和核糖体RNA共价结合的中间体。
Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.
作者信息
Swenson D H, Lin J K, Miller E C, Miller J A
出版信息
Cancer Res. 1977 Jan;37(1):172-81.
PMID:187331
Abstract
Administration of[3H]aflatoxin B2 (2,3-dihydroaflatoxin B1)(AFB2) to male rats resulted in levels of hepatic DNA- and ribosomal(r)RNA-aflatoxin adducts that were about 1% of those for rats given [3H]aflatoxin B1(AFB1). The levels of hepatic protein-aflatoxin adducts were 35 to 70% as great for AFB2-treated as compared to AFB1-treated rats...
摘要
给雄性大鼠施用[3H]黄曲霉毒素B2（2,3-二氢黄曲霉毒素B1）（AFB2）后，肝脏DNA和核糖体（r）RNA-黄曲霉毒素加合物的水平约为给予[3H]黄曲霉毒素B1（AFB1）的大鼠的1%。与AFB1处理的大鼠相比，AFB2处理的大鼠肝脏蛋白质-黄曲霉毒素加合物的水平为其35%至70%……
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