Sidney S, Quesenberry C P, Sadler M C, Guess H A, Lydick E G, Cattolica E V
Kaiser Permanente Medical Care Program, West Point, PA.
Cancer Causes Control. 1991 Mar;2(2):113-6. doi: 10.1007/BF00053130.
The relationship of vasectomy to prostate cancer was studied in 5,119 men men with a self-reported history of vasectomy, identified at multiphasic health checkups undergone during 1977-82 while members of the Northern California Kaiser Permanente Medical Care Program. Three unvasectomized comparison subjects were identified for each vasectomized man, matched for age, race, marital status, and date and location of the examination. Follow-up for incident prostate cancer was conducted for a mean length of 6.8 years. The relative risk of prostate cancer associated with vasectomy was 1.0 (95% confidence interval = 0.7 - 1.6); the relative risk was approximately one, regardless of length of interval (less than 10 years, 10-20 years, more than 20 years) between vasectomy and multiphasic health checkup or the age at vasectomy (less than 40 years vs more than 40 years). These data support earlier findings reported in this study group of the lack of an association of vasectomy with subsequent risk of prostate cancer.
在1977年至1982年期间，作为北加利福尼亚凯撒医疗保健项目的成员，5119名有自我报告输精管切除术史的男性在多阶段健康检查中被识别出来，对输精管切除术与前列腺癌的关系进行了研究。为每一名接受输精管切除术的男性确定三名未接受输精管切除术的对照对象，根据年龄、种族、婚姻状况以及检查日期和地点进行匹配。对前列腺癌发病情况的随访平均时长为6.8年。与输精管切除术相关的前列腺癌相对风险为1.0（95%置信区间=0.7-1.6）；无论输精管切除术与多阶段健康检查之间的间隔时长（少于10年、10至20年、超过20年）或输精管切除术时的年龄（小于40岁与大于40岁）如何，相对风险均约为1。这些数据支持了该研究组之前报告的输精管切除术与后续前列腺癌风险缺乏关联的研究结果。
