Klausen T, Mohr T, Ghisler U, Nielsen O J
Department of Clinical Physiology and Nuclear Medicine, University Hospital of Fredriksberg, Denmark.
Eur J Appl Physiol Occup Physiol. 1991;62(5):376-9. doi: 10.1007/BF00634976.
Six well-trained male cross-county skiers trained for 7 days at 2700 m above sea level, their accommodation being at 1695 m. Blood samples for haemoglobin concentration [Hb], erythropoietin concentration [EPO] and reticulocyte count were collected before, during and after altitude exposure. Packed cell volume (PCV), red blood cell count (RBC), transferrin-iron saturation, mean red cell volume (MCV), mean corpuscular haemoglobin concentration (MCHC), maximal oxygen uptake, maximal achieved ventilation and heart rate were determined pre- and postaltitude exposure. The [EPO] increased significantly from pre-altitude (mean 36 mU.ml-1, SD 5) to maximal altitude values (mean 47 mU.ml-1, SD 3). The [Hb] had increased significantly above pre-altitude values (mean 8.8 mmol.l-1, SD 0.5) on day 2 (mean 9.1 mmol.l-1, SD 0.4) and day 7 (mean 9.4 mmol.l-1, SD 0.4) at altitude and on day 4 postaltitutde (mean 9.2 mmol.l-1, SD 0.4). The reticulocyte counts had increased significantly above pre-altitude values (mean 6%, SD 3%) on day 3 at altitude (mean 12%, SD 8%) and day 4 postaltitude (mean 10%, SD 5%). The RBC counts had increased on the 4th postaltitude day. The transferrin-iron saturation had decreased below pre-altitude values (mean 23%, SD 4%) on day 4 postaltitude (mean 14%, SD 5%) and had increased on day 11 postaltitude (mean 22%, SD 7%). There were no significant changes in MCV, MCHC, PCV, maximal oxygen uptake and maximal achieved ventilation, and heart rate pre- to postaltitude. These observations demonstrated an erythropoietic response to the altitude training which was not sufficient to increase the postaltitude maximal oxygen uptake.
六名训练有素的男性越野滑雪运动员在海拔2700米处进行了7天的训练，他们居住在海拔1695米处。在海拔暴露前、期间和之后采集血样，检测血红蛋白浓度[Hb]、促红细胞生成素浓度[EPO]和网织红细胞计数。在海拔暴露前后测定血细胞比容（PCV）、红细胞计数（RBC）、转铁蛋白-铁饱和度、平均红细胞体积（MCV）、平均红细胞血红蛋白浓度（MCHC）、最大摄氧量、最大通气量和心率。[EPO]从海拔暴露前（平均36 mU.ml-1，标准差5）显著增加到海拔最高值（平均47 mU.ml-1，标准差3）。海拔第2天（平均9.1 mmol.l-1，标准差0.4）、第7天（平均9.4 mmol.l-1，标准差0.4）以及海拔暴露后第4天（平均9.2 mmol.l-1，标准差0.4）时，[Hb]显著高于海拔暴露前的值（平均8.8 mmol.l-1，标准差0.5）。海拔第3天（平均12%，标准差8%）和海拔暴露后第4天（平均10%，标准差5%）时，网织红细胞计数显著高于海拔暴露前的值（平均6%，标准差3%）。海拔暴露后第4天红细胞计数增加。海拔暴露后第4天转铁蛋白-铁饱和度低于海拔暴露前的值（平均23%，标准差4%）（平均14%，标准差5%），海拔暴露后第11天有所增加（平均22%，标准差7%）。海拔暴露前后MCV、MCHC、PCV、最大摄氧量、最大通气量和心率无显著变化。这些观察结果表明，对高原训练有红细胞生成反应，但不足以增加海拔暴露后的最大摄氧量。
