Levy R, Segal K, Hadar T, Shvero J, Abraham A
Department of Otolaryngology, Beilinson Medical Center, Petah Tiqva, Israel.
Eur J Surg Oncol. 1991 Aug;17(4):330-4.
Between 1958 and 1983 at Beilinson Medical Center, Petah Tiqva, Israel, 75 patients were diagnosed as having squamous cell carcinoma of the body of the tongue. Of these, 42 were male and 33 female and the average age at the time of diagnosis was 61.6 years. 29.33% were in clinical stage I, 36% in stage II, 26.67% in stage III and 8% in stage IV. Fifteen patients underwent only surgery, nine received only irradiation and 51 received combined treatment. The 5-year survival rate was 68.3% with a significant difference between that for stage I (90%) and stage II (83.7%) and that for stages III and IV (43.07% and 0%, respectively) (P less than 0.001). Among the 24 with recurrence of the malignancy, 20 died despite treatment and four patients died of causes unrelated to the malignancy. From this experience it was concluded that local excision of the tumor should be performed only in stage I patients and that in stage II patients prophylactic treatment of the neck (neck dissection and irradiation) should be undertaken because of the high incidence of occult metastases.
1958年至1983年间，在以色列佩塔提克瓦的贝林森医疗中心，75例患者被诊断为舌体鳞状细胞癌。其中，男性42例，女性33例，诊断时的平均年龄为61.6岁。29.33%处于临床I期，36%处于II期，26.67%处于III期，8%处于IV期。15例患者仅接受了手术，9例仅接受了放疗，51例接受了综合治疗。5年生存率为68.3%，I期（90%）和II期（83.7%）与III期和IV期（分别为43.07%和0%）之间存在显著差异（P小于0.001）。在24例恶性肿瘤复发的患者中，20例尽管接受了治疗仍死亡，4例患者死于与恶性肿瘤无关的原因。从这一经验得出的结论是，仅应对I期患者进行肿瘤局部切除，而对于II期患者，由于隐匿性转移的发生率较高，应进行颈部预防性治疗（颈部清扫和放疗）。
