Sipponen T, Kärkkäinen P, Savilahti E, Kolho K-L, Nuutinen H, Turunen U, Färkkilä M
Division of Gastroenterology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Aliment Pharmacol Ther. 2008 Nov 15;28(10):1221-9. doi: 10.1111/j.1365-2036.2008.03835.x. Epub 2008 Aug 26.
Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn's disease (SES-CD) and with histological findings are as yet limited. Aim To study the correlation of faecal calprotectin and lactoferrin with SES-CD and histology.
During 87 consecutive ileocolonoscopies, SES-CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured.
In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES-CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES-CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448).
In ileocolonic and colonic disease, endoscopic score SES-CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal-marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.
粪便钙卫蛋白和乳铁蛋白越来越多地作为炎症性肠病（IBD）疾病活动的替代标志物。关于这些标志物与克罗恩病简单内镜评分（SES-CD）及组织学结果之间相关性的数据仍然有限。目的：研究粪便钙卫蛋白和乳铁蛋白与SES-CD及组织学的相关性。
在连续87例回结肠镜检查过程中，计算SES-CD并从回肠、结肠和直肠获取活检标本。检测粪便钙卫蛋白和乳铁蛋白。
在回结肠或结肠疾病中，粪便钙卫蛋白和乳铁蛋白均与结肠SES-CD（P < 0.001）及结肠组织学（P < 0.001）显著相关。在钙卫蛋白或乳铁蛋白水平正常的患者中，内镜和组织学评分显著低于浓度升高的患者（P < 0.001）。在回肠克罗恩病中，回肠SES-CD与组织学相关（P < 0.001），但与粪便钙卫蛋白（P = 0.161）或乳铁蛋白（P = 0.448）无关。
在回结肠和结肠疾病中，内镜评分SES-CD及组织学结果与粪便钙卫蛋白和乳铁蛋白显著相关。粪便标志物浓度正常是内镜及组织学上无活动的克罗恩病的可靠替代标志物。然而，回肠内镜评分和组织学结果与粪便标志物无相关性。
