Piotrovskii V K
Laboratory of Pharmacokinetics, Center for Preventive Medicine, Moscow, USSR.
J Pharmacokinet Biopharm. 1991 Jun;19(3):311-8. doi: 10.1007/BF03036253.
A model structure-independent method for calculating the true elimination rate constant of a primary metabolite is presented. It does not require direct metabolite administration and uses data on drug and metabolite blood (plasma) concentrations after a bolus drug input. The method has been tested and compared with the moment method and the area function method using errorless and errant data simulated on the basis of one- and two-compartment models of the metabolite kinetics. In contrast to known methods the proposed method provided exact estimates of the elimination rate constant in the case of errorless data of both one- and two-compartment models. However the estimates are sensitive to random errors in the concentration data.
本文提出了一种计算主要代谢物真实消除速率常数的与模型结构无关的方法。该方法不需要直接给予代谢物，而是利用单次静脉注射药物后药物和代谢物血液（血浆）浓度的数据。该方法已通过基于代谢物动力学的一室和二室模型模拟的无误差和有误差数据进行了测试，并与矩量法和面积函数法进行了比较。与已知方法不同，该方法在一室和二室模型的无误差数据情况下能够提供消除速率常数的准确估计。然而，这些估计对浓度数据中的随机误差很敏感。
