Cheng H Y, Jusko W J
Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo 14260.
J Pharmacokinet Biopharm. 1989 Feb;17(1):125-30. doi: 10.1007/BF01059091.
A simple method for determination of the apparent elimination rate constant of a metabolite (km) has been developed. This procedure requires calculation of area intervals under the plasma concentration-time curves of the parent drug and its derived metabolite. The method has been evaluated and compared with the Chan moment method using both errorless and errant data. The approach is accurate for various ratios of elimination rate constants of drug and metabolite, allows several values of km to be averaged, but works best using data prior to the metabolite tmax.
已开发出一种测定代谢物表观消除速率常数（km）的简单方法。该程序需要计算母体药物及其衍生代谢物的血浆浓度-时间曲线下的面积间隔。已使用无误差和有误差的数据对该方法进行了评估，并与Chan矩量法进行了比较。该方法对于药物和代谢物消除速率常数的各种比值都是准确的，允许对多个km值进行平均，但在代谢物达峰时间（tmax）之前使用数据时效果最佳。
