Grodums E I, Zbitnew A
Infect Immun. 1976 Dec;14(6):1322-31. doi: 10.1128/iai.14.6.1322-1331.1976.
Herpes simplex virus types 1 and 2 induced acute and chronic cardiac damage in suckling and weaning mice after intranasal inoculation. Signs of virus replication were detected by light, immunofluorescent, and electron microscopy techniques. Virtually all of the cardiac tissues appeared to be susceptible to herpes simplex virus. The myocardium, however, was most regularly affected. The viral lesions were discrete during the acute phase of infection. The cardiac damage, however, was more extensive in some of the chronically infected mice. Morphologically, these lesions either resembled the acute ones or were associated with inflammatory granulomatous and sclerotic changes.
单纯疱疹病毒1型和2型经鼻内接种后可在乳鼠和断奶小鼠中引起急性和慢性心脏损伤。通过光学显微镜、免疫荧光显微镜和电子显微镜技术检测到病毒复制迹象。实际上，所有心脏组织似乎都易受单纯疱疹病毒感染。然而，心肌最常受到影响。在感染急性期，病毒损伤是离散的。然而，在一些慢性感染小鼠中，心脏损伤更为广泛。从形态学上看，这些损伤要么类似于急性损伤，要么与炎性肉芽肿和硬化性改变有关。
