I期肾细胞癌的流式细胞术脱氧核糖核酸分析

Flow cytometric deoxyribonucleic acid analysis in stage I renal cell carcinoma.

作者信息

Ljungberg B, Larsson P, Stenling R, Roos G

机构信息

Departments of Urology, University of Umeå, Sweden.

出版信息

J Urol. 1991 Sep;146(3):697-9. doi: 10.1016/s0022-5347(17)37896-5.

DOI:10.1016/s0022-5347(17)37896-5

PMID:1875475

Abstract

Tumor deoxyribonucleic acid (DNA) content was analyzed by flow cytometry in 60 consecutive patients with stage I renal cell carcinoma. Of 59 evaluable tumors 27 (46%) were homogeneously diploid, 1 (2%) was tetraploid and 31 (52%) were aneuploid. Of the 32 nondiploid tumors 25 were heterogeneous concerning ploidy. One of the 27 patients with diploid tumors had metastases compared to 5 of the 32 patients with nondiploid tumors (not significant). There was a significant difference in survival between patients with diploid and nondiploid tumors (p = 0.043). Neither nuclear grade, tumor cell type nor tumor size correlated with survival. Analysis of DNA content seems to predict survival significantly for patients with stage I renal cell carcinoma.

摘要

采用流式细胞术对60例连续的Ⅰ期肾细胞癌患者的肿瘤脱氧核糖核酸（DNA）含量进行了分析。在59个可评估的肿瘤中，27个（46%）为均匀二倍体，1个（2%）为四倍体，31个（52%）为非整倍体。在32个非二倍体肿瘤中，25个在倍体方面存在异质性。27例二倍体肿瘤患者中有1例发生转移，而32例非二倍体肿瘤患者中有5例发生转移（无显著性差异）。二倍体和非二倍体肿瘤患者的生存率存在显著差异（p = 0.043）。核分级、肿瘤细胞类型和肿瘤大小均与生存率无关。DNA含量分析似乎能显著预测Ⅰ期肾细胞癌患者的生存率。