Bernstein Gerald
Albert Einstein College of Medicine, 48 Carleon Avenue, Larchmont, NY 10538, USA.
Expert Opin Drug Deliv. 2008 Sep;5(9):1047-55. doi: 10.1517/17425247.5.9.1047.
The burgeoning number of people with diabetes mellitus is a global problem. Simple but effective treatment with minimal side effects will be required to reduce the risk for macro- and micro-vascular complications. A big part of this goal can be achieved by the ready administration of insulin with or without other medications.
The RapidMist drug delivery system places human recombinant insulin in a liquid formulation so as to be delivered to the buccal mucosa with an asthma-like device. As with nitroglycerin, the insulin PK-PD is very fast, thus affording flexibility.
Serial data show clinical efficacy in Type 1 and Type 2 diabetes with at least non-inferiority to regular insulin.
糖尿病患者数量的迅速增长是一个全球性问题。需要采用简单但有效的治疗方法，且副作用最小，以降低大血管和微血管并发症的风险。通过使用或不使用其他药物直接给予胰岛素，很大程度上可以实现这一目标。
快速喷雾药物递送系统将人重组胰岛素制成液体制剂，以便通过类似哮喘治疗的装置递送至颊黏膜。与硝酸甘油一样，胰岛素的药代动力学-药效学过程非常迅速，因此具有灵活性。
系列数据表明，该系统对1型和2型糖尿病具有临床疗效，至少与常规胰岛素相当。
