趋化作用中的信号转导。
Signal relay during chemotaxis.
作者信息
Garcia G L, Parent C A
机构信息
Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
出版信息
J Microsc. 2008 Sep;231(3):529-34. doi: 10.1111/j.1365-2818.2008.02066.x.
The ability of cells to migrate in response to external cues, a process known as chemotaxis, is a fundamental phenomenon in biology. It is exhibited by a wide variety of cell types in the context of embryogenesis, angiogenesis, inflammation, wound healing and many other complex physiological processes. Here, we discuss the signals that control the directed migration of the social amoebae Dictyostelium discoideum both as single cells and in the context of group migration. This multi-cellular organism has served as an excellent model system to decipher amoeboid-like leukocyte migration and has played a key role in establishing signalling paradigms in the chemotaxis field. We envision that Dictyostelium will continue to bring forward basic knowledge as we seek to understand the mechanisms regulating group cell migration.
细胞响应外部信号进行迁移的能力，即趋化作用，是生物学中的一个基本现象。在胚胎发育、血管生成、炎症、伤口愈合及许多其他复杂生理过程中，多种细胞类型都会表现出这种能力。在此，我们讨论控制社会变形虫盘基网柄菌单细胞及群体迁移时定向迁移的信号。这种多细胞生物已成为解析类变形虫白细胞迁移的优秀模型系统，并在趋化作用领域信号传导模式的建立中发挥了关键作用。我们设想，在我们试图理解调控群体细胞迁移的机制时，盘基网柄菌将继续提供基础知识。
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