在一项针对接受辅助化疗的乳腺癌患者的前瞻性研究中，未发现认知副作用的迹象。
No indications of cognitive side-effects in a prospective study of breast cancer patients receiving adjuvant chemotherapy.
作者信息
Mehlsen Mimi, Pedersen Anders Degn, Jensen Anders Bonde, Zachariae Robert
机构信息
Department of Psychology, University of Aarhus, Aarhus C, Denmark.
出版信息
Psychooncology. 2009 Mar;18(3):248-57. doi: 10.1002/pon.1398.
OBJECTIVE
A number of cross-sectional studies have reported reduced cognitive function in cancer patients receiving chemotherapy compared with other cancer patients and healthy controls, suggesting that chemotherapy could be associated with cognitive side-effects. Recently published prospective studies question this hypothesis, but it is still unclear whether cancer patients should regard cognitive problems as a potential risk when receiving chemotherapy.
METHODS
In the present study we examine whether cancer patients (n=34) receiving chemotherapy differed in cognitive changes during treatment compared with cardiac patients (n=12) and healthy controls (n=12) tested at 3-4 months interval.
RESULTS
Our results showed no differences with respect to changes in cognitive performance over time between cancer patients in chemotherapy, cardiac patients, and healthy controls. In addition, the number of individuals showing reliable decline or improvement on cognitive tests did not differ between groups.
CONCLUSION
Taken together, our results do not support a hypothesis of cognitive side-effects of standard-dose chemotherapy in breast cancer patients.
目的
多项横断面研究报告称，与其他癌症患者及健康对照相比，接受化疗的癌症患者认知功能有所下降，这表明化疗可能与认知副作用有关。最近发表的前瞻性研究对这一假设提出了质疑，但癌症患者在接受化疗时是否应将认知问题视为潜在风险仍不明确。
方法
在本研究中，我们比较了接受化疗的癌症患者（n = 34）与每隔3 - 4个月进行测试的心脏病患者（n = 12）及健康对照（n = 12）在治疗期间认知变化是否存在差异。
结果
我们的结果显示，化疗中的癌症患者、心脏病患者和健康对照在认知表现随时间的变化方面没有差异。此外，在认知测试中表现出可靠下降或改善的个体数量在各组之间也没有差异。
结论
综上所述，我们的结果不支持标准剂量化疗会对乳腺癌患者产生认知副作用这一假设。
Zotero 插件