Kyriakopoulos Christos, Zarkavelis George, Andrianopoulou Artemis, Papoudou-Bai Alexandra, Stefanou Dimitrios, Boussios Stergios, Pentheroudakis George
Department of Pulmonary Medicine, Medical School, University of Ioannina, Stavros Niarchos Avenue, 45110 Ioannina, Greece.
Department of Medical Oncology, Medical School, University of Ioannina, Stavros Niarchos Avenue, 45110 Ioannina, Greece; Society for Study of the Clonal Heterogeneity of Neoplasia, Ioannina, Greece.
Case Rep Oncol Med. 2017;2017:8654326. doi: 10.1155/2017/8654326. Epub 2017 Mar 2.
Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are extremely rare. Published data on primary pulmonary malignant melanomas are limited. Up to now 40 relevant cases have been reported in the English literature. Herein, we report a case of a 56-year-old female patient who presented with intracranial metastases due to primary pulmonary melanoma. She underwent bronchoscopy and died 5 months after the initial diagnosis despite the administered biochemotherapy and subsequent immunotherapy. To establish the diagnosis of primary pulmonary malignant melanoma, any extrapulmonary origin was excluded by detailed examination and radiographic imaging. Moreover, an extensive review of the literature regarding this rare entity has been performed.
累及呼吸道的恶性黑色素瘤几乎总是转移性的，原发性肿瘤极为罕见。关于原发性肺恶性黑色素瘤的已发表数据有限。截至目前，英文文献中已报道了40例相关病例。在此，我们报告一例56岁女性患者，因原发性肺黑色素瘤出现颅内转移。她接受了支气管镜检查，尽管接受了生物化疗及随后的免疫治疗，但在初次诊断后5个月死亡。为确立原发性肺恶性黑色素瘤的诊断，通过详细检查和影像学检查排除了任何肺外起源。此外，还对关于这一罕见实体的文献进行了广泛回顾。
