Modorati G, Miserocchi E, Galli L, Picozzi P, Rama P
Department of Ophthalmology, San Raffaele Scientific Institute, Milan, Italy, Via Olgettina 60, 20132 Milan, Italy.
Br J Ophthalmol. 2009 Jan;93(1):40-4. doi: 10.1136/bjo.2008.142208. Epub 2008 Aug 29.
To present our treatment protocol and evaluate the results of Gamma knife radiosurgery (GKR) in treating patients with uveal melanoma.
Seventy-eight consecutive patients with uveal melanoma underwent stereotactic radiosurgery (radiation dose 30-50 Gy) with a Leksell Gamma-Knife at the San Raffaele University Hospital, Milan, Italy between 1994 and 2006. The main outcome measures evaluated were: survival rate, local tumour control, eye retention rate, visual acuity and treatment-related complications.
Survival rate was 88.8% at 3 years and 81.9% at 5 years. Local tumour control was achieved in 91.0% of patients. The median tumour thickness reduction after treatment was 1.96 mm (p<0.0001) (-32.1%). The eye retention rate was 89.7%. A significant relative reduction of visual acuity was observed during follow-up. The most frequent treatment-related complications were: exudative retinopathy (33.3%), neovascular glaucoma (18.7%), radiogenic retinopathy (13.5%) and vitreous haemorrhages (10.4%).
GKR can be considered an alternative to enucleation for the treatment of choroidal melanomas.
介绍我们的治疗方案并评估伽玛刀放射外科治疗（GKR）葡萄膜黑色素瘤患者的结果。
1994年至2006年期间，意大利米兰圣拉斐尔大学医院对78例连续性葡萄膜黑色素瘤患者使用Leksell伽玛刀进行立体定向放射外科治疗（放射剂量30 - 50 Gy）。评估的主要结局指标包括：生存率、局部肿瘤控制、眼球保留率、视力和治疗相关并发症。
3年生存率为88.8%，5年生存率为81.9%。91.0%的患者实现了局部肿瘤控制。治疗后肿瘤厚度中位数减少1.96 mm（p<0.0001）（-32.1%）。眼球保留率为89.7%。随访期间观察到视力有显著相对下降。最常见的治疗相关并发症为：渗出性视网膜病变（33.3%）、新生血管性青光眼（18.7%）、放射性视网膜病变（13.5%）和玻璃体积血（10.4%）。
GKR可被视为脉络膜黑色素瘤治疗中眼球摘除术的一种替代方法。
Zotero 插件