Hacettepe University Faculty of Medicine, Department of Radiation Oncology, Ankara, Turkey.
Curr Treat Options Oncol. 2024 Jul;25(7):932-951. doi: 10.1007/s11864-024-01212-5. Epub 2024 Jun 13.
Uveal melanoma is the most common primary ocular tumor in adults. With the evidence demonstrating that episcleral plaque brachytherapy (EPB) has similar survival rates as enucleation in the Collaborative Ocular Melanoma Study (COMS), eye-sparing treatments have come to the fore today. External radiotherapy techniques (proton beam radiotherapy and stereotactic radiosurgery/fractionated stereotactic radiosurgery) are an important treatment option for globe-sparing treatments. There are no prospective randomized trials comparing these techniques; however, retrospective series, meta-analyses, and reviews indicate that these EPB and external radiotherapy techniques are equal. With this review, we aimed to examine the external radiotherapy techniques used in the treatment of uveal melanoma in detail with reference to the current literature.
葡萄膜黑色素瘤是成年人中最常见的原发性眼部肿瘤。有证据表明，巩膜敷贴放疗（EPB）在协作性眼黑色素瘤研究（COMS）中的生存率与眼球摘除术相当，因此今天眼球保留治疗已成为主流。外部放射治疗技术（质子束放疗和立体定向放射外科/分次立体定向放射外科）是眼球保留治疗的重要选择。目前尚无比较这些技术的前瞻性随机试验；然而，回顾性系列、荟萃分析和综述表明，这些 EPB 和外部放射治疗技术是等效的。在这篇综述中，我们旨在参考当前文献，详细检查用于治疗葡萄膜黑色素瘤的外部放射治疗技术。
