首发精神病中的神经学异常与认知能力
Neurological abnormalities and cognitive ability in first-episode psychosis.
作者信息
Dazzan Paola, Lloyd Tuhina, Morgan Kevin D, Zanelli Jolanta, Morgan Craig, Orr Ken, Hutchinson Gerard, Fearon Paul, Allin Matthew, Rifkin Larry, McGuire Philip K, Doody Gillian A, Holloway John, Leff Julian, Harrison Glynn, Jones Peter B, Murray Robin M
机构信息
Department of Psychiatry, Box 63, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.
出版信息
Br J Psychiatry. 2008 Sep;193(3):197-202. doi: 10.1192/bjp.bp.107.045450.
BACKGROUND
It remains unclear if the excess of neurological soft signs, or of certain types of neurological soft signs, is common to all psychoses, and whether this excess is simply an epiphenomenon of the lower general cognitive ability present in psychosis.
AIMS
To investigate whether an excess of neurological soft signs is independent of diagnosis (schizophrenia v. affective psychosis) and cognitive ability (IQ).
METHOD
Evaluation of types of neurological soft signs in a prospective cohort of all individuals presenting with psychoses over 2 years (n=310), and in a control group from the general population (n=239).
RESULTS
Primary (P<0.001), motor coordination (P<0.001), and motor sequencing (P<0.001) sign scores were significantly higher in people with any psychosis than in the control group. However, only primary and motor coordination scores remained higher when individuals with psychosis and controls were matched for premorbid and current IQ.
CONCLUSIONS
Higher rates of primary and motor coordination signs are not associated with lower cognitive ability, and are specific to the presence of psychosis.
背景
目前尚不清楚神经软体征过多，或某些类型的神经软体征过多，是否在所有精神病中都常见，以及这种过多是否仅仅是精神病中普遍存在的较低一般认知能力的一种附带现象。
目的
研究神经软体征过多是否独立于诊断（精神分裂症与情感性精神病）和认知能力（智商）。
方法
对一个前瞻性队列中的神经软体征类型进行评估，该队列包括在两年内出现精神病症状的所有个体（n = 310），以及来自普通人群的对照组（n = 239）。
结果
任何精神病患者的主要（P < 0.001）、运动协调（P < 0.001）和运动序列（P < 0.001）体征得分均显著高于对照组。然而，当根据病前和当前智商对精神病患者和对照组个体进行匹配时，只有主要和运动协调得分仍然较高。
结论
主要和运动协调体征的较高发生率与较低的认知能力无关，且是精神病所特有的。
Zotero 插件