Rogojan Liliana, Olinici C D
Department of Pathology, County Hospital Cluj-Napoca, Romania.
Rom J Morphol Embryol. 2008;49(3):403-6.
Ganglioglioma with a glioblastomatous component and high-grade atypia of neuronal cells are extremely rare findings. In this paper, we report the case of a 60-year-old man who presented with a tumor of the left temporal lobe. Hematoxylin-Eosin stained slides revealed a complex tumor with features of glioblastoma and marked atypia of neuronal cells. Glial cells were highlightened by antibodies to GFAP and neuronal cells by chromogranin and synaptophysin markers. There was an accumulation of p53-positive cells. There was a high Ki-67 labelling index (19%).
伴有胶质母细胞瘤成分和神经元细胞高度异型性的神经节胶质瘤是极其罕见的发现。在本文中，我们报告了一例60岁男性，其患有左颞叶肿瘤。苏木精-伊红染色切片显示为具有胶质母细胞瘤特征和明显神经元细胞异型性的复杂肿瘤。胶质细胞通过抗GFAP抗体进行标记，神经元细胞通过嗜铬粒蛋白和突触素标记物进行标记。存在p53阳性细胞的积聚。Ki-67标记指数较高（19%）。
