Andersson Olle, Möller Riitta Ylitalo, Finizia Caterina, Ruth Magnus
Department of Otolaryngology-Head and Neck Surgery, Sahlgrenska University Hospital, SE-41345 Göteborg, Sweden.
Scand J Gastroenterol. 2009;44(1):23-31. doi: 10.1080/00365520802321279.
To evaluate the development of pharyngeal and esophageal acid exposure, symptoms, and laryngeal findings in previously healthy subjects.
Thirty-three subjects, previously included in a normative pH monitoring study, completed symptom questionnaires, a video laryngoscopic examination, and ambulatory 24-h pharyngeal and esophageal pH monitoring after a mean follow-up of 14 years.
Twenty-four subjects (15 F, 9 M, mean age 57 years) completed the study. The number of subjects with pathological esophageal reflux increased from 5 (21%) at baseline to 8 (33%) at follow-up (p=0.23), whereas the proportion with pharyngeal acid exposure of at least 0.1% decreased from 42% to 13% (p=0.04). Heartburn and/or regurgitation developed in 11 of the 24 (46%) subjects and airway symptoms in 10 (42%) subjects. Laryngeal pathology was found in 9 of 23 subjects (39%). Airway symptoms were equally common among subjects with and those without laryngeal findings or with and without pharyngeal reflux.
Esophageal acid exposure increases over time in previously symptom-free, healthy subjects. The increase in airway symptoms or laryngeal abnormalities is not directly related to increased acid exposure.
评估既往健康受试者的咽喉和食管酸暴露情况、症状及喉部检查结果的发展变化。
33名曾参与正常pH监测研究的受试者，在平均随访14年后，完成了症状问卷、视频喉镜检查以及24小时动态咽喉和食管pH监测。
24名受试者（15名女性，9名男性，平均年龄57岁）完成了研究。病理性食管反流受试者数量从基线时的5名（21%）增至随访时的8名（33%）（p = 0.23），而咽喉酸暴露至少达0.1%的受试者比例从42%降至13%（p = 0.04）。24名受试者中有11名（46%）出现烧心和/或反流，10名（42%）出现气道症状。23名受试者中有9名（39%）发现喉部病变。有喉部检查结果和无喉部检查结果的受试者以及有咽喉反流和无咽喉反流的受试者中，气道症状的出现频率相当。
在既往无症状的健康受试者中，食管酸暴露随时间增加。气道症状或喉部异常的增加与酸暴露增加无直接关系。
