Carlsen Berit Christina, Menné Torkil, Johansen Jeanne Duus
Department of Dermatology and Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Ledreborg Allé 40, 1., 2820 Gentofte, Denmark.
Contact Dermatitis. 2008 Aug;59(2):96-102. doi: 10.1111/j.1600-0536.2008.01400.x.
Identification of patients at risk of developing polysensitization is not possible at present. An association between weak sensitizers and polysensitization has been hypothesized.
To examine associations of 21 allergens in the European baseline series to polysensitization.
PATIENTS/METHODS: From a database-based study with 14 998 patients patch tested with the European baseline series between 1985 and 2005, a group of 759 (5.1%) patients were polysensitized. Odds ratios were calculated to determine the relative contribution of each allergen to polysensitization.
Seven allergens--parabens mix, N-isopropyl-N-phenyl-p-phenylenediamine, sesquiterpene lactone mix, wool alcohols, potassium dichromate, Myroxylon pereirae, and cobalt chloride - showed statistically significant positive associations to polysensitization. Five allergens p-phenylenediamine, neomycin sulfate, epoxy resin, primin, and nickel sulfate showed statistically significant negative associations to polysensitization. For the allergens with the strongest associations, only every second individual with these particular allergies had two or more additional allergies.
No common denominator for the association between the allergens and the polysensitization was apparent, and any association, whether positive or negative, was relatively low. Based on these results, sensitization to specific baseline allergens cannot be used as risk indicators for polysensitization.
目前尚无法识别有发生多重致敏风险的患者。已有人提出弱致敏原与多重致敏之间存在关联。
研究欧洲基线系列中21种变应原与多重致敏之间的关联。
患者/方法：在一项基于数据库的研究中，对1985年至2005年间用欧洲基线系列进行斑贴试验的14998例患者进行分析，其中759例（5.1%）患者发生了多重致敏。计算优势比以确定每种变应原对多重致敏的相对影响。
七种变应原——对羟基苯甲酸酯混合物、N-异丙基-N-苯基对苯二胺、倍半萜内酯混合物、羊毛醇、重铬酸钾、秘鲁胶和氯化钴——与多重致敏呈统计学显著正相关。五种变应原——对苯二胺、硫酸新霉素、环氧树脂、致敏原和硫酸镍——与多重致敏呈统计学显著负相关。对于相关性最强的变应原，这些特定过敏患者中只有半数有两种或更多其他过敏。
变应原与多重致敏之间没有明显的共同特征，任何关联，无论是正相关还是负相关，都相对较低。基于这些结果，对特定基线变应原的致敏不能用作多重致敏的风险指标。
