Wang Huaiyu, Ji Junhui, Zhang Wei, Zhang Yihe, Jiang Jiang, Wu Zhengwei, Pu Shihao, Chu Paul K
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Acta Biomater. 2009 Jan;5(1):279-87. doi: 10.1016/j.actbio.2008.07.017. Epub 2008 Jul 31.
Poly(butylene succinate) (PBSu), a novel biodegradable aliphatic polyester with excellent processability and mechanical properties, is a promising substance for bone and cartilage repair. However, it typically suffers from insufficient biocompatibility and bioactivity after implantation into the human body. In this work, H(2)O or NH(3) plasma immersion ion implantation (PIII) is conducted for the first time to modify the PBSu surface. Both the treated and control specimens are characterized by X-ray photoelectron spectroscopy, contact angle measurements and atomic force microscopy. The plasma treatments improve the hydrophilicity and roughness of PBSu significantly and the different PIII processes result in similar hydrophilicity and topography. C-OH and C-NH(2) functional groups emerge on the PBSu surface after H(2)O and NH(3) PIII, respectively. The biological results demonstrate that both osteoblast compatibility and apatite formability are enhanced after H(2)O and NH(3) PIII. Furthermore, our results suggest that H(2)O PIII is more effective in rendering PBSu suitable for bone-replacement implants compared to NH(3) PIII.
聚丁二酸丁二醇酯（PBSu）是一种新型的可生物降解脂肪族聚酯，具有优异的加工性能和机械性能，是用于骨和软骨修复的一种有前景的材料。然而，它植入人体后通常存在生物相容性和生物活性不足的问题。在这项工作中，首次进行了H₂O或NH₃等离子体浸没离子注入（PIII）来改性PBSu表面。通过X射线光电子能谱、接触角测量和原子力显微镜对处理后的和对照样品进行了表征。等离子体处理显著提高了PBSu的亲水性和粗糙度，不同的PIII工艺导致了相似的亲水性和表面形貌。H₂O和NH₃ PIII处理后，PBSu表面分别出现了C-OH和C-NH₂官能团。生物学结果表明，H₂O和NH₃ PIII处理后，成骨细胞相容性和磷灰石形成能力均得到增强。此外，我们的结果表明，与NH₃ PIII相比，H₂O PIII在使PBSu适合骨替代植入物方面更有效。
