Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
ACS Appl Mater Interfaces. 2012 Aug;4(8):4380-6. doi: 10.1021/am301033t. Epub 2012 Jul 25.
Artificial implants are alternatives to autologous grafts in repairing severe bone damage and in many clinical applications, the artificial implant materials should be biodegradable in order to avoid chronic problems associated with biostable implants. In this study, a biodegradable biopolymer, poly(butylene succinate) (PBSu), is treated by N(2), NH(3) and H(2)O plasmas and investigated as bone replacement materials in vitro to obtain a better understanding of the behavior of osteoblasts on the different plasma-treated materials. N(2), NH(3), and H(2)O plasma immersion ion implantation (PIII) produces dominant C-N, C═N, and C-O surface functional groups, respectively rendering the materials with hydrophilic characteristics which favor osteoblast adhesion and early proliferation. In particular, N-containing groups, especially C═N, are more positive to osteogenic differentiation of the seeded osteoblasts than C-O. Among the 3 plasma treatments, NH(3) PIII is the most effective, yielding surface properties that are suitable for artificial bone implants.
人工植入物是修复严重骨损伤的自体移植物的替代品，在许多临床应用中，为了避免与生物稳定植入物相关的慢性问题，人工植入物材料应该是可生物降解的。在这项研究中，采用 N(2)、NH(3) 和 H(2)O 等离子体处理可生物降解的生物聚合物聚丁二酸丁二醇酯（PBSu），并将其作为骨替代材料进行体外研究，以更好地了解成骨细胞在不同等离子体处理材料上的行为。N(2)、NH(3) 和 H(2)O 等离子体浸没式离子注入（PIII）分别产生主要的 C-N、C═N 和 C-O 表面官能团，使材料具有亲水性，有利于成骨细胞黏附和早期增殖。特别是含 N 基团，尤其是 C═N，比 C-O 更有利于种子成骨细胞的成骨分化。在 3 种等离子体处理中，NH(3) PIII 最有效，产生适合人工骨植入物的表面性能。
