Takeda Shu
Department of Orthopaedic Surgery, Tokyo Medical and Dental School Graduate School, Tokyo, Japan.
Int J Biochem Cell Biol. 2009 Mar;41(3):455-9. doi: 10.1016/j.biocel.2008.08.002. Epub 2008 Aug 7.
Osteoporosis is caused by a failure of bone homeostasis, but the precise molecular mechanisms controlling bone homeostasis are largely unknown. Increasing evidence that neurons and neurotransmitters are intimately involved in bone remodelling has shed light on a novel regulatory mechanism for bone homeostasis. Namely, like all other homeostatic functions, bone remodelling is under the control of the hypothalamus, and osteoporosis is considered to be a neuroskeletal disease.
骨质疏松症是由骨稳态失衡引起的，但控制骨稳态的精确分子机制在很大程度上尚不清楚。越来越多的证据表明，神经元和神经递质密切参与骨重塑，这为骨稳态的一种新的调节机制提供了线索。也就是说，与所有其他稳态功能一样，骨重塑受下丘脑控制，骨质疏松症被认为是一种神经骨骼疾病。
