Song Wenxia, Condron Sara, Mocca Brian T, Veit Sandra J, Hill Dawn, Abbas Asima, Jerse Ann E
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA.
Vaccine. 2008 Oct 23;26(45):5741-51. doi: 10.1016/j.vaccine.2008.08.020. Epub 2008 Aug 30.
The 17beta-estradiol-treated mouse model is the only small animal model of gonococcal genital tract infection. Here we show gonococci localized within vaginal and cervical tissue, including the lamina propria, and high numbers of neutrophils and macrophages in genital tissue from infected mice. Infection did not induce a substantial or sustained increase in total or gonococcal-specific antibodies. Mice could be reinfected with the same strain and repeat infection did not boost the antibody response. However, intravaginal immunization of estradiol-treated mice induced gonococcal-specific primary and secondary serum antibody responses. We conclude that similar to human infection, experimental murine infection induces local inflammation but not an acquired immune response or immunological memory.
17β-雌二醇处理的小鼠模型是唯一的淋球菌生殖道感染小动物模型。在此我们展示了淋球菌定位于阴道和宫颈组织内，包括固有层，并且在感染小鼠的生殖组织中有大量中性粒细胞和巨噬细胞。感染并未导致总抗体或淋球菌特异性抗体的显著或持续增加。小鼠可以被同一菌株再次感染，重复感染并未增强抗体反应。然而，对经雌二醇处理的小鼠进行阴道内免疫可诱导淋球菌特异性的初次和二次血清抗体反应。我们得出结论，与人类感染相似，实验性小鼠感染诱导局部炎症，但不诱导获得性免疫反应或免疫记忆。
