Ruíz-Cendoya Mery, Rodriguez M Mar, Mariné Marçal, Pastor F Javier, Guarro Josep
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
Int J Antimicrob Agents. 2008 Nov;32(5):418-20. doi: 10.1016/j.ijantimicag.2008.05.015. Epub 2008 Aug 30.
The in vitro interactions between itraconazole and micafungin against 133 strains of filamentous fungi of clinical interest were evaluated using a checkerboard method. Overall, synergistic interactions were observed against 30% of the strains tested. In the cases of Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Fonsecaea spp. and Sporothrix schenckii, synergistic interactions were observed against > or = 50% of the strains tested. For the rest of the fungi the interaction was indifferent; antagonism was not observed in any case.
采用棋盘法评估了伊曲康唑和米卡芬净对133株具有临床意义的丝状真菌的体外相互作用。总体而言，在30%的受试菌株中观察到协同相互作用。在烟曲霉、黄曲霉、土曲霉、镰刀菌属和申克孢子丝菌的病例中，在≥50%的受试菌株中观察到协同相互作用。对于其余真菌，相互作用无明显差异；在任何情况下均未观察到拮抗作用。
