Venugopal P V, Venugopal T V
Institute of Microbiology, Madurai Medical College, Madras, India.
Indian J Pathol Microbiol. 1995 Oct;38(4):345-8.
The in vitro activity of itraconazole was investigated against 25 clinical isolates of filamentous fungi by agar dilution method. The isolated included Aspergillus sp., hyalohypomycetes, dematiaceous fungi and zygomycetes. Intraconazole was more active, inhibiting 50% (MIC 50) and 90% (MIC 90) of the Aspergillus sp., at a concentration of 0.5 and 2.5 ug ml-1 (MIC range 0.1 and 5 micrograms ml-1) Ketoconazole (MIC range 0.5-10 ug ml-1) required 1 and 5 ug ml-1 for inhibiting 50% and 90% of the isolates. For the hyalophypomycetes and dematiaceous fungi, the MIC 50s for itraconazole were 1 and 0.5 ug ml-1 and Ketoconazole required 2.5 ug ml-1 for both the groups. For the zygomycetes, the MIC range and MIC 50s for Ketoconazole were 1-100 and 10 ug ml-1 whereas the values for itraconazole were 5- > 100 and > 100 micrograms ml-1.
采用琼脂稀释法研究了伊曲康唑对25株丝状真菌临床分离株的体外活性。分离株包括曲霉属、透明丝孢霉、暗色真菌和接合菌。伊曲康唑活性更强，在浓度为0.5和2.5微克/毫升（MIC范围为0.1至5微克/毫升）时，可抑制50%（MIC50）和90%（MIC90）的曲霉属菌株。酮康唑（MIC范围为0.5至10微克/毫升）抑制50%和90%的分离株分别需要1和5微克/毫升。对于透明丝孢霉和暗色真菌，伊曲康唑的MIC50分别为1和0.5微克/毫升，酮康唑对这两组均需要2.5微克/毫升。对于接合菌，酮康唑的MIC范围和MIC50分别为1至100和10微克/毫升，而伊曲康唑的值分别为5至>100和>100微克/毫升。
