多个中心体：合则存，分则亡。
Multiple centrosomes: together they stand, divided they fall.
作者信息
Gergely Fanni, Basto Renata
机构信息
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Department of Oncology, University of Cambridge, Cambridge CB2 0RE, United Kingdom.
出版信息
Genes Dev. 2008 Sep 1;22(17):2291-6. doi: 10.1101/gad.1715208.
Abstract
Cells with extra centrosomes rely entirely on centrosome clustering mechanisms to assemble a bipolar spindle and to divide in a bipolar fashion. To identify the pathways involved in suppression of multipolarity, Kwon, Godinho, and colleagues (pp. 2189-2203) have set up a genome-wide screen in Drosophila S2 cells. Surprisingly, they found that efficient clustering requires a large number of proteins associated with a variety of cellular functions.
摘要
具有额外中心体的细胞完全依赖中心体聚集机制来组装双极纺锤体并以双极方式进行分裂。为了确定参与抑制多极性的途径，权、戈迪尼奥及其同事（第2189 - 2203页）在果蝇S2细胞中进行了全基因组筛选。令人惊讶的是，他们发现高效聚集需要大量与多种细胞功能相关的蛋白质。
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本文引用的文献
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Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.抑制具有额外中心体的癌细胞中多极分裂的机制。
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Centrosome amplification can initiate tumorigenesis in flies.中心体扩增可在果蝇中引发肿瘤发生。
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Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells.肌动蛋白结合蛋白和其激活激酶Slik是有丝分裂细胞中皮质稳定性和微管组织所必需的。
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Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis.膜突蛋白在有丝分裂过程中控制皮质硬度、细胞变圆和纺锤体形态发生。
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Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris.关于西奥多·博韦里所著的《恶性肿瘤的起源》。由亨利·哈里斯翻译并注释。
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