Yalcin Tok Ozlem, Burcu Nurozler Ayse, Ergun Gul, Akbas Kocaoglu Fatma, Duman Sunay
Department of Ophthalmology, Ankara Education and Research Hospital, Ankara, Turkey.
Ophthalmologica. 2008;222(6):391-6. doi: 10.1159/000151740. Epub 2008 Sep 1.
To investigate the efficacy and safety of postoperative topical cyclosporine A 0.05% (tCsA) (Restasis, Allergan Pharmaceutical) eye drops in preventing the recurrence of pterygium.
31 patients with bilateral pterygium were examined between January 2006 and February 2007. During a 1-year follow-up, the right eyes of the patients assigned as the treatment group were treated by tCsA and the left eyes were considered as the control group.
The pterygium recurred in 4 (12.9%) of 31 right eyes in the treatment group and in 14 (45.2%) of 31 left eyes in the control group (p = 0.005). The mean follow-up +/- SD was 9.39 +/- 4.14 months (range, 1 to 12 months). The control group had a 7.37 times higher risk of recurrence in pterygium compared with the treatment group (OR = 0.1357, p = 0.0051). A statistically significant difference in recurrence-free probabilities was found for the treatment and control groups (log-rank test; p = 0.006). A multivariate Cox regression model showed that age (p = 0.0093) and tCsA (p = 0.0103) were independent statistically significant impacts on recurrence-free time for pterygium.
This study suggests that primary excision of pterygium with postoperative instillation of 0.05% cyclosporine is both safe and efficient.
研究术后局部应用0.05%环孢素A（tCsA）（Restasis，Allergan制药公司）滴眼液预防翼状胬肉复发的有效性和安全性。
2006年1月至2007年2月间对31例双侧翼状胬肉患者进行检查。在1年的随访期间，将患者的右眼作为治疗组用tCsA治疗，左眼作为对照组。
治疗组31只右眼中有4只（12.9%）翼状胬肉复发，对照组31只左眼中有14只（45.2%）复发（p = 0.005）。平均随访时间±标准差为9.39±4.14个月（范围1至12个月）。与治疗组相比，对照组翼状胬肉复发风险高7.37倍（OR = 0.1357，p = 0.0051）。治疗组和对照组在无复发概率上存在统计学显著差异（对数秩检验；p = 0.006）。多变量Cox回归模型显示年龄（p = 0.0093）和tCsA（p = 0.0103）对翼状胬肉无复发时间有独立的统计学显著影响。
本研究表明，翼状胬肉初次切除术后滴注0.05%环孢素是安全有效的。
