Özülken Kemal, Koç Mustafa, Ayar Orhan, Hasiripi Hikmet
3rd Clinic of Ophthalmology, Ankara Numune Education and Research Hospital, Ankara - Turkey.
Eur J Ophthalmol. 2012;22 Suppl 7:S5-10. doi: 10.5301/ejo.5000004.
To evaluate the success rate of topical cyclosporine A (tCsA) (Restasis, Allergan) in preventing the recurrence of pterygium excision and conjunctival flap rotation technique in patients applying to our clinic and diagnosed with pterygium.
A total of 56 eyes with primary pterygium in 56 patients were examined and operated with pterygium excision and conjunctival flap rotation technique between October 2008 and September 2009. A total of 26 eyes of these 56 patients were treated with tCsA (Restasis, Allergan) for 6 months during the postoperative period and assigned as the treatment group. The other 30 eyes of 56 patients were assigned as the control group. The operated patients were followed up for approximately 11 months.
The 2 groups were similar in age, sex, and pterygial size. The largest percentage of the patients were farmers (30.3%). The pterygium recurred in 8 (14.2%) of 56 patients; 2 of them were in the treatment group (7.7%) and 6 of them were in the control group (20.0%). There was not any complication threatening vision among operated patients. Recurrence rates between the control and treatment group were statistically significant (p<0.05). The complication and postoperative compliance rates were lower in the treatment group than the control group. The difference between preoperative and postoperative Schirmer I test results among the treatment and control group was statistically significant (p<0.05). The Schirmer I test results increased after tCsA treatment for patients assigned to the treatment group.
The results suggest that tCsA (Restasis, Allergan) can be used safely and effectively after pterygium surgery to obtain lower rates of recurrence.
评估局部应用环孢素A（Restasis，爱尔康公司）预防翼状胬肉切除联合结膜瓣转位术患者翼状胬肉复发的成功率，这些患者来自于我院并被诊断为翼状胬肉。
2008年10月至2009年9月期间，共对56例原发性翼状胬肉患者的56只眼进行了检查，并采用翼状胬肉切除联合结膜瓣转位术进行手术。这56例患者中的26只眼在术后使用局部环孢素A（Restasis，爱尔康公司）治疗6个月，被分配为治疗组。56例患者中的另外30只眼被分配为对照组。对手术患者进行了约11个月的随访。
两组在年龄、性别和翼状胬肉大小方面相似。患者中农民所占比例最大（30.3%）。56例患者中有8例（14.2%）翼状胬肉复发；其中2例在治疗组（7.7%），6例在对照组（20.0%）。手术患者中没有任何威胁视力的并发症。对照组和治疗组之间的复发率具有统计学意义（p<0.05）。治疗组的并发症和术后依从率低于对照组。治疗组和对照组术前和术后泪液分泌试验I结果的差异具有统计学意义（p<0.05）。治疗组患者在使用局部环孢素A治疗后泪液分泌试验I结果有所增加。
结果表明，翼状胬肉手术后安全有效地使用局部环孢素A（Restasis，爱尔康公司）可降低复发率。
