Kollias Costas T, Kontaxakis Vassilis P, Havaki-Kontaxaki Beata J, Stamouli Sophia, Margariti Maria, Petridou Eleni
Department of Psychiatry, Eginition Hospital, University of Athens Medical School, Athens, Greece.
Psychopathology. 2008;41(6):365-70. doi: 10.1159/000152378. Epub 2008 Sep 3.
BACKGROUND/AIMS: Researchers have shown interest in the association between anhedonia and depression in schizophrenia. The aim of the current study was to investigate the relationship between physical and social anhedonia with depression in a sample of inpatients with schizophrenia in the acute phase of their illness.
Sixty-two patients with acute schizophrenia consecutively admitted at the Eginition Hospital, Department of Psychiatry, University of Athens were assessed using the revised Physical Anhedonia Scale, the revised Social Anhedonia Scale and the Calgary Depression Scale for Schizophrenia.
The Calgary Depression Scale for Schizophrenia score correlated with both physical anhedonia and social anhedonia ratings. The revised Social Anhedonia Scale score significantly correlated to self-depreciation, guilty ideas of reference, pathological guilt, early wakening, suicidality and observed depression. The revised Physical Anhedonia Scale score significantly correlated with depressive mood, self-depreciation, pathological guilt and observed depression. Self-depreciation, pathological guilt and observed depression were correlated with both social and physical anhedonia.
Depression in schizophrenia and anhedonia may overlap, and it could therefore be difficult to clinically differentiate them, especially in acute schizophrenia patients.
背景/目的:研究人员已对精神分裂症中快感缺乏与抑郁之间的关联产生兴趣。本研究的目的是在处于疾病急性期的精神分裂症住院患者样本中,调查躯体性快感缺乏和社会性快感缺乏与抑郁之间的关系。
对雅典大学埃吉尼蒂翁医院精神科连续收治的62例急性精神分裂症患者,使用修订后的躯体性快感缺乏量表、修订后的社会性快感缺乏量表以及精神分裂症卡尔加里抑郁量表进行评估。
精神分裂症卡尔加里抑郁量表评分与躯体性快感缺乏和社会性快感缺乏评分均相关。修订后的社会性快感缺乏量表评分与自我贬低、牵连观念、病理性内疚、早醒、自杀倾向及观察到的抑郁显著相关。修订后的躯体性快感缺乏量表评分与抑郁情绪、自我贬低、病理性内疚及观察到的抑郁显著相关。自我贬低、病理性内疚及观察到的抑郁与社会性和躯体性快感缺乏均相关。
精神分裂症中的抑郁和快感缺乏可能重叠,因此临床上可能难以区分它们,尤其是在急性精神分裂症患者中。