Theodossiadis P G, Grigoropoulos V G, Emfietzoglou I, Nikolaidis P, Vergados I, Apostolopoulos M, Theodossiadis G P
2nd Department of Ophthalmology, University of Athens, 13, Likiou Street, 10674 Athens, Greece.
Graefes Arch Clin Exp Ophthalmol. 2009 Jan;247(1):13-20. doi: 10.1007/s00417-008-0927-z. Epub 2008 Sep 3.
To study the natural course of lamellar macular hole (LMH) as examined by optical coherence tomography (OCT) in a noncomparative observational case series.
Forty-one eyes of 41 patients with LMH were included in this analysis. Baseline and final OCT findings related to LMH diameter, foveal thickness and visual acuity (VA) were collected and compared. Mean follow-up was 37.1 months. Main outcome measures were best-corrected visual acuity (BCVA), diameter of the LMH opening, foveal thickness, epiretinal membrane (ERM), posterior vitreous detachment (PVD) and vitreoretinal traction.
The diameter of the LMH increased by an average of 13.7%. A statistically significant association was found between the LMH diameter increase and the presence of ERM. The mean foveal thickness depicted a statistically significant decrease between the initial and the final examination. The decrease of the foveal thickness showed to correlate with visual acuity deterioration. BCVA was stable in 30 (78%) and deteriorated in 11 (22%) cases. In eight of the 11 cases, the visual acuity deterioration ranged from 2 to 15 letters.
We identified an increase of LMH diameter related to the presence of ERM and a decrease of the foveal thickness within a period of observation which ranged from 24 to 54 months (mean 37.1 months).
在一个非对照观察性病例系列中，通过光学相干断层扫描（OCT）研究板层黄斑裂孔（LMH）的自然病程。
本分析纳入了41例LMH患者的41只眼。收集并比较了与LMH直径、黄斑中心凹厚度和视力（VA）相关的基线和最终OCT检查结果。平均随访时间为37.1个月。主要观察指标为最佳矫正视力（BCVA）、LMH开口直径、黄斑中心凹厚度、视网膜前膜（ERM）、玻璃体后脱离（PVD）和玻璃体视网膜牵拉。
LMH直径平均增加了13.7%。发现LMH直径增加与ERM的存在之间存在统计学上的显著关联。初始检查和最终检查之间，黄斑中心凹平均厚度呈现出统计学上的显著下降。黄斑中心凹厚度的下降与视力恶化相关。30例（78%）患者的BCVA稳定，11例（22%）患者的BCVA恶化。在11例患者中的8例中，视力恶化范围为2至15个字母。
我们发现在24至54个月（平均37.1个月）的观察期内，LMH直径增加与ERM的存在有关，且黄斑中心凹厚度下降。
