短翼黄芪和小头黄芪根中的环阿屯烷三萜糖苷。

Cycloartane triterpene glycosides from the roots of Astragalus brachypterus and Astragalus microcephalus.

作者信息

Bedir E, Calis I, Aquino R, Piacente S, Pizza C

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey.

出版信息

J Nat Prod. 1998 Dec;61(12):1469-72. doi: 10.1021/np9801763.

DOI:10.1021/np9801763

PMID:9868145

Abstract

Three new cycloartane-type triterpene glycosides, brachyosides A (1), B (3), and C (2), from the roots of Astragalus brachypterus and one new glycoside, cyclocephaloside II (4), from the roots of Astragalusmicrocephalus have been isolated together with five known saponins, astragalosides I, II, and IV, cyclocanthoside E, and cycloastragenol. The structures of the new compounds were established as 3-O-[beta-D-xylopyranosyl(1-->3)-beta-D-xylopyranosyl-6-O-beta-D-gluc opyranosyl-3beta,6alpha,16beta,24(S),25-pentahydrox ycycloartane (1), 3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-24-O-beta-D-glucop yranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxyc ycloartane (2), 20(R),24(S)-epoxy-6-O-beta-D-glucopyranosyl-3beta,6alpha,16beta , 25-tetrahydroxycycloartane (3), and 20(R), 24(S)-epoxy-3-O-(4'-O-acetyl)-beta-D-xylopyranosyl-6-O-beta-D-glucopy ranosyl-3beta,6alpha,16beta,25-tetrahydroxycycloart ane (4). For the structure elucidations, 1D- and 2D-NMR experiments and FABMS were used.

摘要

从短翼黄芪根部分离得到了三种新的环阿尔廷烷型三萜糖苷，即短翼皂苷A（1）、B（3）和C（2），从微头黄芪根部分离得到了一种新的糖苷，即环头皂苷II（4），同时还分离得到了五种已知的皂苷，即黄芪皂苷I、II和IV、环刺糖苷E和环黄芪醇。新化合物的结构确定为3-O-[β-D-吡喃木糖基(1→3)-β-D-吡喃木糖基-6-O-β-D-吡喃葡萄糖基-3β,6α,16β,24(S),25-五羟基环阿尔廷烷（1）、3-O-β-D-吡喃木糖基-6-O-β-D-吡喃葡萄糖基-24-O-β-D-吡喃葡萄糖基-3β,6α,16β,24(S),25-五羟基环阿尔廷烷（2）、20(R),24(S)-环氧-6-O-β-D-吡喃葡萄糖基-3β,6α,16β,25-四羟基环阿尔廷烷（3）以及20(R),24(S)-环氧-3-O-(4'-O-乙酰基)-β-D-吡喃木糖基-6-O-β-D-吡喃葡萄糖基-3β,6α,16β,25-四羟基环阿尔廷烷（4）。在结构解析过程中，使用了一维和二维核磁共振实验以及快原子轰击质谱。