来自绵果黄芪的环阿尔廷型糖苷。

Cycloartane-type glycosides from Astragalus amblolepis.

作者信息

Polat Emre, Caliskan-Alankus Ozgen, Perrone Angela, Piacente Sonia, Bedir Erdal

机构信息

Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100 Izmir, Turkey.

出版信息

Phytochemistry. 2009 Mar;70(5):628-34. doi: 10.1016/j.phytochem.2009.03.006. Epub 2009 Apr 6.

DOI:10.1016/j.phytochem.2009.03.006

PMID:19356776

Abstract

Five cycloartane-type triterpene glycosides were isolated from the methanol extract of the roots of Astragalus amblolepis Fischer along with one known saponin, 3-O-beta-D-xylopyranosyl-16-O-beta-D-glucopyranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxy-cycloartane. Structures of the compounds were established as 3-O-beta-D-xylopyranosyl-25-O-beta-D-glucopyranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxy-cycloartane, 3-O-[beta-D-glucuronopyranosyl-(1-->2)-beta-D-xylopyranosyl]-25-O-beta-D-glucopyranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxy-cycloartane, 3-O-beta-D-xylopyranosyl-24,25-di-O-beta-D-glucopyranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxy-cycloartane, 6-O-alpha-L-rhamnopyranosyl-16,24-di-O-beta-D-glucopyranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxy-cycloartane, 6-O-alpha-L-rhamnopyranosyl-16,25-di-O-beta-D-glucopyranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxy-cycloartane by using 1D and 2D-NMR techniques and mass spectrometry. To the best of our knowledge, the glucuronic acid moiety in cycloartanes is reported for the first time.

摘要

从绵果黄芪根的甲醇提取物中分离出5种环阿尔廷烷型三萜糖苷以及一种已知皂苷3 - O - β - D - 吡喃木糖基 - 16 - O - β - D - 吡喃葡萄糖基 - 3β,6α,16β,24(S),25 - 五羟基环阿尔廷烷。通过一维和二维核磁共振技术以及质谱分析，确定这些化合物的结构分别为3 - O - β - D - 吡喃木糖基 - 25 - O - β - D - 吡喃葡萄糖基 - 3β,6α,16β,24(S),25 - 五羟基环阿尔廷烷、3 - O - [β - D - 葡萄糖醛酸吡喃糖基 - (1→2) - β - D - 吡喃木糖基] - 25 - O - β - D - 吡喃葡萄糖基 - 3β,6α,16β,24(S),25 - 五羟基环阿尔廷烷、3 - O - β - D - 吡喃木糖基 - 24,25 - 二 - O - β - D - 吡喃葡萄糖基 - 3β,6α,16β,24(S),25 - 五羟基环阿尔廷烷、6 - O - α - L - 鼠李糖吡喃糖基 - 16,24 - 二 - O - β - D - 吡喃葡萄糖基 - 3β,6α,16β,24(S),25 - 五羟基环阿尔廷烷、6 - O - α - L - 鼠李糖吡喃糖基 - 16,25 - 二 - O - β - D - 吡喃葡萄糖基 - 3β,6α,16β,24(S),25 - 五羟基环阿尔廷烷。据我们所知，环阿尔廷烷中的葡萄糖醛酸部分首次被报道。