Radwan Mohamed M, El-Sebakhy Nadia A, Asaad Aya M, Toaima Soad M, Kingston David G I
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, MC 0212, Blacksburg, VA 24061-0212, USA.
Phytochemistry. 2004 Nov;65(21):2909-13. doi: 10.1016/j.phytochem.2004.08.037.
Four cycloartane-type saponins, kahiricosides II-V (1-4), were isolated from the aerial parts of Astragalus kahiricus of Egyptian origin. Their structures were established as 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(2'-O-acetyl)-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(6'-O-acetyl)-beta-D-glucopyranoside, and 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranosyl-27-O-beta-D-glucopyranoside based on chemical and spectral evidences. All compounds exhibited very weak cytotoxicity against the A2780 ovarian cancer cell line.
从埃及产的卡希尔黄芪地上部分分离得到了四种环阿尔廷烷型皂苷，即卡希尔皂苷II - V（1 - 4）。基于化学和光谱证据，确定它们的结构分别为9β，19 - 环羊毛甾 - 24E - 烯 - 3β，6α，16β，27 - 四醇 - 3 - O - β - D - 吡喃葡萄糖苷、9β，19 - 环羊毛甾 - 24E - 烯 - 3β，6α，16β，27 - 四醇 - 3 - O - （2'-O - 乙酰基） - β - D - 吡喃葡萄糖苷、9β，19 - 环羊毛甾 - 24E - 烯 - 3β，6α，16β，27 - 四醇 - 3 - O - （6'-O - 乙酰基） - β - D - 吡喃葡萄糖苷以及9β，19 - 环羊毛甾 - 24E - 烯 - 3β，6α，16β，27 - 四醇 - 3 - O - β - D - 吡喃葡萄糖基 - 27 - O - β - D - 吡喃葡萄糖苷。所有化合物对A2780卵巢癌细胞系均表现出非常弱的细胞毒性。
