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肌肉减少症≠肌肉功能减退。

Sarcopenia =/= dynapenia.

作者信息

Clark Brian C, Manini Todd M

机构信息

Department of Biomedical Sciences, Ohio University, 211 Irvine Hall, Athens, OH 45701, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):829-34. doi: 10.1093/gerona/63.8.829.

Abstract

Maximal voluntary force (strength) production declines with age and contributes to physical dependence and mortality. Consequently, a great deal of research has focused on identifying strategies to maintain muscle mass during the aging process and elucidating key molecular pathways of atrophy, with the rationale that the loss of strength is primarily a direct result of the age-associated declines in mass (sarcopenia). However, recent evidence questions this relationship and in this Green Banana article we argue the role of sarcopenia in mediating the age-associated loss of strength (which we will coin as dynapenia) does not deserve the attention it has attracted in both the scientific literature and popular press. Rather, we propose that alternative mechanisms underlie dynapenia (i.e., alterations in contractile properties or neurologic function), and urge that greater attention be paid to these variables in determining their role in dynapenia.

摘要

最大自主力量(强度)的产生会随着年龄增长而下降,这会导致身体依赖和死亡。因此,大量研究集中于确定在衰老过程中维持肌肉质量的策略,并阐明萎缩的关键分子途径,其基本原理是力量的丧失主要是与年龄相关的肌肉质量下降(肌肉减少症)的直接结果。然而,最近的证据对这种关系提出了质疑,在这篇“绿色香蕉”文章中,我们认为肌肉减少症在介导与年龄相关的力量丧失(我们将其定义为肌力减退)方面所起的作用,并不值得它在科学文献和大众媒体中所吸引到的关注。相反,我们提出肌力减退有其他潜在机制(即收缩特性或神经功能的改变),并敦促在确定这些变量在肌力减退中的作用时,应更多地关注它们。

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