Hao Jiayi, Tang Chunbian, Yang Qingqing, Gu Youyou, Wang Su, Zeng Baoqi
Medical School of Tianjin University, Tianjin, 300072, China.
Department of Endocrinology, Tianjin Fifth Central Hospital (Peking University Binhai Hospital), Tianjin, 300450, China.
Sci Rep. 2025 Aug 27;15(1):31599. doi: 10.1038/s41598-025-16735-6.
Previous studies have shown that diabetes is linked to both low muscle strength and abdominal obesity. However, the combined relationship and synergistic effect on the risk of diabetes in middle-aged and elderly people are still unclear. Using nationally representative data collected between 2011 and 2020 by the China Health and Retirement Longitudinal Study (CHARLS). Dynapenic abdominal obesity was a measure that combined hand grip strength and waist circumference. 7934 participants aged ≥ 45 years were divided into four groups (neither dynapenia nor abdominal obesity, only dynapenia, only abdominal obesity, and dynapenic abdominal obesity). Cox proportional hazards models were used to calculate the association of dynapenic abdominal obesity on diabetes. The reference group comprised participants with neither dynapenia nor abdominal obesity. Dynapenic abdominal obesity was associated with an increased risk of diabetes (HR = 1.52; 95%CI = 1.12-2.05). Only abdominal obesity group also had a higher risk of diabetes (HR = 1.54, 95%CI = 1.32-1.80), and only dynapenia was not statistically associated with the risk of diabetes (HR = 1.05, 95%CI = 0.80-1.39) and sensitivity analysis showed that the results were robust. Dynapenic abdominal obesity and only abdominal obesity might be associated with 52% and 54% higher risk of diabetes, while only dynapenia was not statistically associated with the risk of diabetes.
以往的研究表明，糖尿病与肌肉力量低下和腹部肥胖均有关联。然而，在中老年人中，二者对糖尿病风险的综合关系及协同效应仍不明确。本研究使用了中国健康与养老追踪调查（CHARLS）在2011年至2020年期间收集的具有全国代表性的数据。动态肌无力性腹部肥胖是一种结合了握力和腰围的测量方法。7934名年龄≥45岁的参与者被分为四组（既无动态肌无力也无腹部肥胖、仅有动态肌无力、仅有腹部肥胖、动态肌无力性腹部肥胖）。采用Cox比例风险模型计算动态肌无力性腹部肥胖与糖尿病之间的关联。参照组为既无动态肌无力也无腹部肥胖的参与者。动态肌无力性腹部肥胖与糖尿病风险增加相关（风险比[HR]=1.52；95%置信区间[CI]=1.12 - 2.05）。仅有腹部肥胖组患糖尿病的风险也较高（HR = 1.54，95%CI = 1.32 - 1.80），而仅有动态肌无力与糖尿病风险无统计学关联（HR = 1.05，95%CI = 0.80 - 1.39），敏感性分析表明结果具有稳健性。动态肌无力性腹部肥胖和仅有腹部肥胖可能分别使糖尿病风险升高52%和54%，而仅有动态肌无力与糖尿病风险无统计学关联。
