Saczynski Jane S, Jonsdottir Maria K, Sigurdsson Sigurdur, Eiriksdottir Gudny, Jonsson Palmi V, Garcia Melisa E, Kjartansson Olafur, van Buchem Mark A, Gudnason Vlimundur, Launer Lenore J
Division of Geriatric Medicine, University of Massachusetts Medical School, Biotech Four, 377 Plantation Street, Worcester, MA 01605, USA.
J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):848-54. doi: 10.1093/gerona/63.8.848.
Among persons with white matter lesions (WMLs), there is a range of cognitive function. We examine whether participation in leisure activities modifies the effect of WML load on cognitive function.
Data are from 2300 men and women (aged 66-92 years) participating in the population-based Age Gene/Environment Susceptibility-Reykjavik Study. Subcortical WML load was calculated as a weighted sum, based on size of lesions in the four lobes. Periventricular WML load was calculated as the sum of lesion scores, based on size, for the frontal caps, occipitoparietal caps and bands. The upper quartile of lesion load in either area was compared to the lower three quartiles. Composite scores of memory (MEM), speed of processing (SP), and executive function (EF) were constructed from a battery of neuropsychological tests. Frequency of participation in nine cognitively stimulating leisure activities was assessed via questionnaire; the upper quartile was compared to the lower three quartiles. Multiple regression, controlling for demographic and health factors and brain infarcts, was used to test the main effects and interaction of WMLs and leisure activity on cognitive function.
High leisure activity was associated with higher performance in all three cognitive abilities: MEM beta = 0.20, 95% confidence interval [CI], 0.11-0.29; SP beta = 0.37, 95% CI, 0.29-0.45; and EF beta = 0.23, 95% CI, 0.15-0.29. High WML load was associated with significantly lower performance in SP (beta = -0.06, 95% CI, -0.13 to -0.01). The effect of WMLs on SP performance was modified by high leisure activity (p for interaction <.05).
Participation in cognitively stimulating leisure activity may attenuate the effect of WML pathology on cognitive performance.
在患有白质病变（WMLs）的人群中，存在一系列认知功能。我们研究参与休闲活动是否会改变WML负荷对认知功能的影响。
数据来自参与基于人群的年龄基因/环境易感性 - 雷克雅未克研究的2300名男性和女性（年龄在66 - 92岁之间）。皮质下WML负荷根据四个脑叶病变大小计算为加权总和。脑室周围WML负荷根据额叶帽、枕顶叶帽和带的大小计算病变分数总和。将任一区域病变负荷的上四分位数与下三个四分位数进行比较。记忆（MEM）、处理速度（SP）和执行功能（EF）的综合分数由一系列神经心理学测试构建。通过问卷调查评估参与九种认知刺激休闲活动的频率；将上四分位数与下三个四分位数进行比较。使用多元回归，控制人口统计学和健康因素以及脑梗死，来测试WMLs和休闲活动对认知功能的主要影响和相互作用。
高休闲活动与所有三种认知能力的较高表现相关：MEM β = 0.20，95%置信区间[CI]，0.11 - 0.29；SP β = 0.37，95% CI，0.29 - 0.45；EF β = 0.23，95% CI，0.15 - 0.29。高WML负荷与SP的显著较低表现相关（β = -0.06，95% CI，-0.13至-0.01）。高休闲活动改变了WMLs对SP表现的影响（交互作用p <.05）。
参与认知刺激休闲活动可能会减弱WML病理对认知表现的影响。
