一株抗原性不典型的天花病毒毒株。

An antigenically atypical strain of variola virus.

作者信息

Marennikova S S, Shelukhina E M, Matsevich G R, Habahpasheva N A

出版信息

J Gen Virol. 1976 Dec;33(3):513-5. doi: 10.1099/0022-1317-33-3-513.

Abstract

The Kuwait-5-67 strain of variola virus, although indistinguishable from variola virus in its other properties, behaved atypically in immuno-diffusion tests with antivaccinia serum. The precipitation line pattern produced was similar to that of cowpox virus but lacked one of the main precipitation bands given by all other strains of variola, alastrim and vaccinia viruses tested. Trypsin treatment of cowpox virus preparations revealed the missing precipitation line but did not do so with the Kuwait-5-67 strain. The antivaccinia serum absorbed by Kuwait-5-67 strain lost its ability to interact with this strain, but still gave precipitation lines with variola, vaccinia and cowpox viruses.

摘要

天花病毒的科威特-5-67毒株，尽管在其他特性上与天花病毒无法区分，但在用抗牛痘血清进行免疫扩散试验时表现出非典型性。所产生的沉淀线模式与牛痘病毒相似，但缺少所有其他测试的天花、类天花和牛痘病毒毒株所具有的一条主要沉淀带。用胰蛋白酶处理牛痘病毒制剂可显示出缺失的沉淀线，但对科威特-5-67毒株则无此效果。被科威特-5-67毒株吸收的抗牛痘血清失去了与该毒株相互作用的能力，但仍能与天花、牛痘和牛痘病毒产生沉淀线。