成纤维细胞生长因子-2的低分子量和高分子量蛋白质亚型在心血管发育和疾病中的生物学功能。
Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease.
作者信息
Liao Siyun, Bodmer Janet, Pietras Daniel, Azhar Mohamad, Doetschman Tom, Schultz Jo El J
机构信息
Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio, USA.
出版信息
Dev Dyn. 2009 Feb;238(2):249-64. doi: 10.1002/dvdy.21677.
Abstract
Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low molecular weight, LMW, and high molecular weight, HMW) produced by alternative translation from the Fgf2 gene. These protein isoforms are localized to different cellular compartments, indicating unique biological activity. FGF2 isoforms in the heart have distinct roles in many pathological circumstances in the heart including cardiac hypertrophy, ischemia-reperfusion injury, and atherosclerosis. These studies suggest distinct biological activities of FGF2 LMW and HMW isoforms both in vitro and in vivo. Yet, due to the limitations that only the recombinant FGF2 LMW isoform is readily available and that the FGF2 antibody is nonspecific with regards to its isoforms, much remains to be determined regarding the role(s) of the FGF2 LMW and HMW isoforms in cellular behavior and in cardiovascular development and pathophysiology. This review summarizes the activities of LMW and HMW isoforms of FGF2 in cardiovascular development and disease.
摘要
成纤维细胞生长因子2（FGF2）由Fgf2基因通过可变翻译产生的多种蛋白质异构体（低分子量，LMW，和高分子量，HMW）组成。这些蛋白质异构体定位于不同的细胞区室，表明具有独特的生物学活性。心脏中的FGF2异构体在心脏的许多病理情况下具有不同的作用，包括心脏肥大、缺血再灌注损伤和动脉粥样硬化。这些研究表明FGF2 LMW和HMW异构体在体外和体内均具有独特的生物学活性。然而，由于仅重组FGF2 LMW异构体易于获得且FGF2抗体对其异构体不具有特异性等局限性，关于FGF2 LMW和HMW异构体在细胞行为以及心血管发育和病理生理学中的作用仍有许多有待确定。本综述总结了FGF2的LMW和HMW异构体在心血管发育和疾病中的活性。
相似文献
1
Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease.成纤维细胞生长因子-2的低分子量和高分子量蛋白质亚型在心血管发育和疾病中的生物学功能。
Dev Dyn. 2009 Feb;238(2):249-64. doi: 10.1002/dvdy.21677.
2
Gene targeted ablation of high molecular weight fibroblast growth factor-2.高分子量成纤维细胞生长因子-2的基因靶向敲除
Dev Dyn. 2009 Feb;238(2):351-7. doi: 10.1002/dvdy.21835.
3
The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury.成纤维细胞生长因子 2 高分子量（HMW）异构体在心脏缺血再灌注损伤中的作用。
J Mol Cell Cardiol. 2010 Jun;48(6):1245-54. doi: 10.1016/j.yjmcc.2010.01.014. Epub 2010 Jan 29.
4
The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling.成纤维细胞生长因子-2低分子量异构体的心脏保护作用：JNK信号传导的作用
J Mol Cell Cardiol. 2007 Jan;42(1):106-20. doi: 10.1016/j.yjmcc.2006.10.005. Epub 2006 Dec 5.
5
Roles of different IRES-dependent FGF2 isoforms in the acquisition of the major aggressive features of human metastatic melanoma.不同的内部核糖体进入位点（IRES）依赖性成纤维细胞生长因子2（FGF2）亚型在人类转移性黑色素瘤主要侵袭性特征形成中的作用
J Mol Med (Berl). 2017 Jan;95(1):97-108. doi: 10.1007/s00109-016-1463-7. Epub 2016 Aug 24.
6
Low molecular weight fibroblast growth factor-2 signals via protein kinase C and myofibrillar proteins to protect against postischemic cardiac dysfunction.低分子量成纤维细胞生长因子-2 通过蛋白激酶 C 和肌原纤维蛋白信号传递，防止缺血后心脏功能障碍。
Am J Physiol Heart Circ Physiol. 2013 May 15;304(10):H1382-96. doi: 10.1152/ajpheart.00613.2012. Epub 2013 Mar 11.
7
FGF2 isoforms play distinct roles in tubular epithelial-to-mesenchymal transition in diabetic nephropathy.成纤维细胞生长因子 2 异构体在糖尿病肾病肾小管上皮间质转化中发挥不同作用。
Exp Cell Res. 2022 Nov 15;420(2):113355. doi: 10.1016/j.yexcr.2022.113355. Epub 2022 Sep 15.
8
Phosphoproteomic analysis identifies phospho-Threonine-17 site of phospholamban important in low molecular weight isoform of fibroblast growth factor 2-induced protection against post-ischemic cardiac dysfunction.磷酸化蛋白质组学分析鉴定了在成纤维细胞生长因子 2 低分子量同工型诱导的缺血后心脏功能障碍保护中起重要作用的肌球蛋白轻链磷酸酶磷酸化苏氨酸-17 位。
J Mol Cell Cardiol. 2020 Nov;148:1-14. doi: 10.1016/j.yjmcc.2020.08.006. Epub 2020 Aug 25.
9
Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.低分子量 FGF2 同种型的消融加速了小鼠骨关节炎，而高分子量 FGF2 同种型的缺失则提供了保护。
J Cell Physiol. 2019 Apr;234(4):4418-4431. doi: 10.1002/jcp.27230. Epub 2018 Aug 25.
10
High molecular weight FGF2 isoforms demonstrate canonical receptor-mediated activity and support human embryonic stem cell self-renewal.高分子量成纤维细胞生长因子2（FGF2）亚型表现出典型的受体介导活性，并支持人类胚胎干细胞自我更新。
Stem Cell Res. 2017 May;21:106-116. doi: 10.1016/j.scr.2017.04.006. Epub 2017 Apr 18.
引用本文的文献
1
Co-host ncRNA MIR503HG/miR-503-5p antagonistically interfere with the crosstalk between fibroblasts and microvascular endothelial cells by affecting the production of LMW FGF2 in pterygium.共宿主非编码RNA MIR503HG/miR-503-5p通过影响翼状胬肉中低分子量成纤维细胞生长因子2的产生，拮抗地干扰成纤维细胞与微血管内皮细胞之间的串扰。
Int J Ophthalmol. 2025 Feb 18;18(2):199-208. doi: 10.18240/ijo.2025.02.01. eCollection 2025.
2
FGF2 is secreted in extracellular vesicles from lung cells.成纤维细胞生长因子 2 从肺细胞的细胞外囊泡中分泌出来。
Am J Physiol Lung Cell Mol Physiol. 2024 Sep 1;327(3):L359-L370. doi: 10.1152/ajplung.00225.2023. Epub 2024 Jul 16.
3
Embryonic stem cells overexpressing high molecular weight FGF2 isoform enhance recovery of pre-ganglionic spinal root lesion in combination with fibrin biopolymer mediated root repair.过表达高分子量 FGF2 同工型的胚胎干细胞与纤维蛋白生物聚合物介导的根修复联合增强前节段脊神经根损伤的恢复。
Stem Cell Res Ther. 2024 Mar 5;15(1):63. doi: 10.1186/s13287-024-03676-6.
4
mRNA sequencing reveals the distinct gene expression and biological functions in cardiac fibroblasts regulated by recombinant fibroblast growth factor 2.mRNA 测序揭示了重组成纤维细胞生长因子 2 调控的心肌成纤维细胞中独特的基因表达和生物学功能。
PeerJ. 2023 Jul 19;11:e15736. doi: 10.7717/peerj.15736. eCollection 2023.
5
The Microenvironment of the Pathogenesis of Cardiac Hypertrophy.心肌肥厚发病机制的微环境。
Cells. 2023 Jul 4;12(13):1780. doi: 10.3390/cells12131780.
6
Cardiac RNase Z edited via CRISPR-Cas9 drives heart hypertrophy in Drosophila.通过 CRISPR-Cas9 编辑的心脏 RNase Z 可驱动果蝇心脏肥大。
PLoS One. 2023 May 25;18(5):e0286214. doi: 10.1371/journal.pone.0286214. eCollection 2023.
7
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression.外源性 FGF 信号在调节成纤维细胞向肌成纤维细胞分化和细胞外基质蛋白表达中的作用。
Open Biol. 2022 Sep;12(9):210356. doi: 10.1098/rsob.210356. Epub 2022 Sep 14.
8
FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis.FGFRL1 和 FGF 基因与身高、高血压和骨质疏松症有关。
PLoS One. 2022 Aug 18;17(8):e0273237. doi: 10.1371/journal.pone.0273237. eCollection 2022.
9
FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells.成纤维细胞生长因子 2 在哮喘中过表达，并通过气道上皮细胞中的 FGFR/MAPK/NF-κB 通路促进气道炎症。
Mil Med Res. 2022 Jan 29;9(1):7. doi: 10.1186/s40779-022-00366-3.
10
A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition.心脏线粒体 FGFR1 介导 FGF2 异构体对渗透性转换的相反作用。
Cells. 2021 Oct 13;10(10):2735. doi: 10.3390/cells10102735.
本文引用的文献
1
Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat.大鼠心肌肥大发展过程中FGF-2与透明质酸的平行上调。
Cell Tissue Res. 2008 Apr;332(1):49-56. doi: 10.1007/s00441-007-0562-8. Epub 2008 Jan 15.
2
Functional evolutionary history of the mouse Fgf gene family.小鼠Fgf基因家族的功能进化史。
Dev Dyn. 2008 Jan;237(1):18-27. doi: 10.1002/dvdy.21388.
3
Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center.成纤维细胞生长因子与刺猬因子：位于心外膜信号中心的核心部位。
Trends Genet. 2008 Jan;24(1):33-40. doi: 10.1016/j.tig.2007.10.007. Epub 2007 Dec 3.
4
Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.正常和异常心脏发育过程中的心外膜衍生细胞（EPDCs）的起源、命运及功能
ScientificWorldJournal. 2007 Nov 12;7:1777-98. doi: 10.1100/tsw.2007.294.
5
Selective translation of mRNAs in the left ventricular myocardium of the mouse in response to acute pressure overload.小鼠左心室心肌中mRNA的选择性翻译对急性压力超负荷的反应。
J Mol Cell Cardiol. 2008 Jan;44(1):69-75. doi: 10.1016/j.yjmcc.2007.10.011. Epub 2007 Oct 25.
6
Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor (FGF-2): a novel mechanism for the control of FGF-2 and thrombin activity.凝血酶可切割碱性成纤维细胞生长因子（FGF - 2）的高分子量形式：一种控制FGF - 2和凝血酶活性的新机制。
Oncogene. 2008 Apr 17;27(18):2594-601. doi: 10.1038/sj.onc.1210899. Epub 2007 Oct 29.
7
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.血管内皮生长因子-A是视网膜神经元的一种存活因子，也是缺血性损伤适应性反应过程中的一种关键神经保护剂。
Am J Pathol. 2007 Jul;171(1):53-67. doi: 10.2353/ajpath.2007.061237.
8
Valvulogenesis: the moving target.瓣膜发生：不断变化的目标。
Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1489-503. doi: 10.1098/rstb.2007.2130.
9
Growth factor modulation of fibroblast proliferation, differentiation, and invasion: implications for tissue valve engineering.生长因子对成纤维细胞增殖、分化和侵袭的调节作用：对组织瓣膜工程的意义。
Tissue Eng. 2006 Oct;12(10):2707-16. doi: 10.1089/ten.2006.12.2707.
10
Fibroblast growth factor-2 and cardioprotection.成纤维细胞生长因子-2与心脏保护作用
Heart Fail Rev. 2007 Dec;12(3-4):267-77. doi: 10.1007/s10741-007-9027-0.
Zotero 插件