Danysh Brian P, Duncan Melinda K
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Exp Eye Res. 2009 Feb;88(2):151-64. doi: 10.1016/j.exer.2008.08.002. Epub 2008 Aug 16.
The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both the structure and biomechanics of the lens in addition to providing informational cues to maintain lens cell phenotype. This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.
晶状体囊是一种经过修饰的基底膜,它完全包裹着眼球晶状体。已知这种细胞外基质除了提供维持晶状体细胞表型的信息线索外,对晶状体的结构和生物力学也很重要。本文综述了晶状体囊的发育和结构、与细胞外基质基因突变相关的晶状体疾病,以及晶状体囊在晶状体功能中的作用,包括那些与视觉调节、对感染因子的选择性通透性和细胞信号传导有关的作用。