Low P A
J Neurol Sci. 1976 Dec;30(2-3):327-41. doi: 10.1016/0022-510x(76)90138-6.
The Trembler mouse suffers from a dominantly inherited chronic hypertrophic neuropathy. Quantitative light-microscopic studies have been performed on Trembler peripheral nerves from birth to adulthood, and compared with the findings in age-matched control mice. Teased fibres of Trembler nerves contained virtually no myelin, nodes of Ranvier were difficult to identify, and supernumerary Schwann cells were prominent. Results of quantitative studies performed on the dorsal root ganglia and spinal cord of Trembler mice did not differ from those in controls. The density of myelinated fibres in the case of Tremblers was reduced at all ages when compared with controls, and there was a predominant loss of large diameter fibres.
颤抖鼠患有一种显性遗传的慢性肥厚性神经病变。已对从出生到成年的颤抖鼠外周神经进行了定量光学显微镜研究，并与年龄匹配的对照小鼠的研究结果进行了比较。颤抖鼠神经的 teased 纤维几乎不含髓磷脂，郎飞结难以识别，且多余的施万细胞很突出。对颤抖鼠的背根神经节和脊髓进行的定量研究结果与对照组无异。与对照组相比，颤抖鼠在所有年龄段的有髓纤维密度均降低，且大直径纤维有明显损失。
