Sharifi F, Mousavinasab S N, Soruri R, Saeini M, Dinmohammadi M
Department of Clinical Endocrinology, Zanjan University of Medical Sciences, Zanjan, Iran.
Metab Syndr Relat Disord. 2008 Sep;6(3):187-95. doi: 10.1089/met.2008.0007.
This study was designed to determine the prevalence of different atherogenic dyslipidemic phenotypes, especially decreased serum high-density lipoprotein cholesterol (HDL-C) in an Iranian population and its relationship to other coronary artery disease (CAD) risk factor.
The prevalence of lipid abnormalities was assessed in 2941 people, including 1396 males and 1545 females, aged more than 20 years. The population is representative of Iranian urban adults living in northwestern Iran. In addition to isolated forms of hypertriglyceridemia, hypercholesterolemia, and hypoalphalipoproteinemia, some dyslipidemic phenotypes including hypertriglyceridemia/low high-density lipoprotein (HDL) combination, mixed dyslipidemias, and severe dyslipidemias were assessed.
The most prevalent abnormality was low HDL cholesterol (HDL-C; 73% including 63% for men and 93.3% for women). Hypertriglyceridemia (>150 mg/dL) was the second most prevalent abnormality (40.6%). Increased total cholesterol (>200 mg/dL) was observed in 35.4% of the subjects. The combination of hypertriglyceridemia and low HDL-C was observed in 9.9% of the population. Fifty eight percent of the low HDL-C cases were not accompanied with hypertriglyceridemia, and 24.4% of hypertriglyceridemic subjects had low HDL-C. Among subjects younger than 30 years, 19% had hypercholesterolemia, 13% had isolated low HDL-C less than 35 mg/dL, and 63% had HDL-C less than 40 mg/dL. Unexpectedly, except for the hypertriglyceridemia/low HDL-C pattern, which was more common in males, the other abnormal lipid profiles were more common in females.
The prevalence of dyslipidemia, especially low HDL cholesterol, in Iranian adults is very high. Urgent preventive programs and changes in lifestyle are needed in this area.
本研究旨在确定不同致动脉粥样硬化血脂异常表型的患病率，尤其是伊朗人群中血清高密度脂蛋白胆固醇（HDL-C）降低的情况及其与其他冠状动脉疾病（CAD）危险因素的关系。
对2941人进行了血脂异常患病率评估，其中包括1396名男性和1545名女性，年龄超过20岁。该人群代表了生活在伊朗西北部的城市成年人群。除了单纯形式的高甘油三酯血症、高胆固醇血症和低α脂蛋白血症外，还评估了一些血脂异常表型，包括高甘油三酯血症/低高密度脂蛋白（HDL）组合、混合型血脂异常和重度血脂异常。
最常见的异常是低HDL胆固醇（HDL-C；73%，男性为63%，女性为93.3%）。高甘油三酯血症（>150mg/dL）是第二常见的异常（40.6%）。35.4%的受试者总胆固醇升高（>200mg/dL）。9.9%的人群存在高甘油三酯血症和低HDL-C的组合。58%的低HDL-C病例不伴有高甘油三酯血症，24.4%的高甘油三酯血症患者HDL-C较低。在30岁以下的受试者中，19%患有高胆固醇血症，13%有单纯的HDL-C低于35mg/dL，63%的HDL-C低于40mg/dL。出乎意料的是，除了高甘油三酯血症/低HDL-C模式在男性中更常见外，其他异常血脂谱在女性中更常见。
伊朗成年人血脂异常的患病率，尤其是低HDL胆固醇的患病率非常高。该领域需要紧急的预防计划和生活方式的改变。
