Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Sci Rep. 2021 Apr 28;11(1):9125. doi: 10.1038/s41598-021-88680-z.
Dyslipidemia, a major risk factor for cardiovascular diseases, has become a global issue. Due to the variations in the prevalence of dyslipidemia, this study aimed to evaluate dyslipidemia and its associated factors in women of the Bandare-Kong Cohort Study (BKNCD). This study was conducted on women from the population-based BKNCD, as part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN). Sociodemographic data, medical history, and anthropometric indices were collected. Dyslipidemia was defined as any lipid abnormality including low-density lipoprotein (LDL) ≥ 160, total cholesterol (TC) ≥ 240, high-density lipoprotein (HDL) < 40, or triglyceride > 200 mg/dl. From the 2223 women in this study (mean age: 48.28 ± 9.26 years), dyslipidemia was observed in 851 (38.3%). High TC was the most common lipid abnormality (18.5%) followed by high LDL (17.7%). Dyslipidemia was most prevalent among women aged 55-70 years, the married, those with < 6 years of education, the unemployed, the overweight or obese, with low socioeconomic status, diabetes, hypertension, and high waist circumference, those using the hookah and living in urban areas. Logistic regression revealed that women with high waist-to-hip ratio (WHR) (OR = 2.22, 95% CI 1.60-3.08), those aged 45-54 years (OR = 1.34, 95% CI 1.07-1.68) and 55-70 years (OR = 1.33, 95% CI 1.03-1.72), and those living in urban areas (OR = 1.35, 95% CI 1.05-1.73) were at significantly increased risk of dyslipidemia. In addition, the results were confirmed using deep neural network models. Dyslipidemia was highly prevalent in Iranian women in the southern coastal region. Central obesity, age over 45 years, and living in urban areas appear to be relatively significant risk factors for dyslipidemia among women.
血脂异常是心血管疾病的主要危险因素,已成为全球性问题。由于血脂异常的流行率存在差异,本研究旨在评估班达尔-孔队列研究(BKNCD)中女性的血脂异常及其相关因素。这项研究是在基于人群的 BKNCD 女性中进行的,是伊朗前瞻性流行病学研究(PERSIAN)的一部分。收集了社会人口统计学数据、病史和人体测量指数。血脂异常定义为任何脂质异常,包括低密度脂蛋白(LDL)≥160、总胆固醇(TC)≥240、高密度脂蛋白(HDL)<40 或甘油三酯>200mg/dl。在这项研究的 2223 名女性中(平均年龄:48.28±9.26 岁),有 851 名(38.3%)患有血脂异常。高 TC 是最常见的脂质异常(18.5%),其次是高 LDL(17.7%)。血脂异常在 55-70 岁的女性中最为常见,其次是已婚女性、受教育年限<6 年的女性、失业女性、超重或肥胖女性、社会经济地位较低的女性、患有糖尿病、高血压和高腰围的女性、使用水烟的女性和居住在城市地区的女性。逻辑回归显示,腰臀比(WHR)高的女性(OR=2.22,95%CI 1.60-3.08)、45-54 岁的女性(OR=1.34,95%CI 1.07-1.68)和 55-70 岁的女性(OR=1.33,95%CI 1.03-1.72)以及居住在城市地区的女性(OR=1.35,95%CI 1.05-1.73)患血脂异常的风险显著增加。此外,使用深度神经网络模型也验证了该结果。血脂异常在伊朗南部沿海地区的女性中非常普遍。腹部肥胖、年龄超过 45 岁和居住在城市地区似乎是女性血脂异常的相对显著危险因素。