Brown L M, Dosemeci M, Blair A, Burmeister L
Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892.
Am J Epidemiol. 1991 Aug 15;134(4):348-55. doi: 10.1093/oxfordjournals.aje.a116096.
Information from surrogates is increasingly being used in case-control studies to evaluate cancer risks from pesticides; however, little is known about the quality of this type of information. To address this concern, the authors compared interview data collected in 1987 from 95 male Iowa farmers and their wives or other surrogates on the use of specific agricultural pesticides. Agreement between direct and surrogate interviews was excellent (83-100%) for responses to dichotomous (yes/no) questions regarding past agricultural use of specific pesticides. Although there were more discrepancies for detailed questions (e.g., the number of days per year on which each pesticide was handled), responses from spouses appear to be adequate for epidemiologic studies of pesticides and cancer.
在病例对照研究中，越来越多地使用来自替代者的信息来评估农药导致的癌症风险；然而，对于这类信息的质量却知之甚少。为了解决这一问题，作者比较了1987年从95名爱荷华州男性农民及其妻子或其他替代者那里收集到的关于特定农业农药使用情况的访谈数据。对于过去农业使用特定农药的二分法（是/否）问题的回答，直接访谈和替代者访谈之间的一致性非常好（83%-100%）。尽管对于详细问题（例如，每年处理每种农药的天数）存在更多差异，但配偶的回答似乎足以用于农药与癌症的流行病学研究。
