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Design and synthesis of peptide-oligonucleotide conjugates as potential artificial ribonucleases.

作者信息

Serpokrylova Inna, Koroleva Ludmila, Svischeva Nadezhda, Novopashina Daria, Silnikov Vladimir

机构信息

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Lavrent'ev ave. 8, Novosibirsk, Russia.

出版信息

Nucleic Acids Symp Ser (Oxf). 2008(52):529-30. doi: 10.1093/nass/nrn268.

DOI:10.1093/nass/nrn268
PMID:18776487
Abstract

A series of peptide-oligonucleotide conjugates was synthesized. The peptide fragment was attached to the middle part of DNA sequence. For this purpose the new amidophosphite dC with linker at C5-position was synthesized.

摘要

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