Mailaparambil Beena, Krueger Marcus, Heinze Jessica, Forster Johannes, Heinzmann Andrea
Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.
Dis Markers. 2008;25(1):59-65. doi: 10.1155/2008/619595.
Toll like receptors (TLRs) are an essential part of the innate immune response. So far, ten different TLRs were identified in humans. They recognize a wide range of microbial and viral pathogens. Infection by respiratory syncytial virus (RSV) is still a major health problem, about 2% of all children are hospitalised due to RSV bronchiolitis during their first 2 years of live. TLR4 has already been described in association with RSV associated diseases by us and others. Thus we were interested whether other TLRs are also involved in the genetics of severe RSV infection. We genotyped 19 polymorphisms in the autosomal TLRs, these are TLR1, 2, 3, 5, 6, 9 and 10. Association analyses by the Armitage's Trend test revealed weak association of one TLR9 promoter polymorphism with RSV infection (p = 0.013). In addition, association was found with TLR10 haplotypes (p = 0.024). We conclude from our data--that--although we can not rule out a minor involvement of TLR9 polymorphism and TLR10 haplotypes--TLRs other than TLR4 do not play a major role in the genetics of severe RSV associated diseases. Future studies should focus on additional genes of the innate immune response.
Toll样受体（TLRs）是先天性免疫反应的重要组成部分。到目前为止，已在人类中鉴定出十种不同的TLRs。它们可识别多种微生物和病毒病原体。呼吸道合胞病毒（RSV）感染仍是一个主要的健康问题，约2%的儿童在其生命的头两年因RSV细支气管炎住院。我们和其他人已经描述了TLR4与RSV相关疾病的关联。因此，我们想知道其他TLRs是否也参与严重RSV感染的遗传学。我们对常染色体TLRs中的19个多态性进行了基因分型，这些TLRs包括TLR1、2、3、5、6、9和10。通过阿米蒂奇趋势检验进行的关联分析显示，一种TLR9启动子多态性与RSV感染存在弱关联（p = 0.013）。此外，还发现与TLR10单倍型存在关联（p = 0.024）。我们从数据中得出结论——尽管我们不能排除TLR9多态性和TLR10单倍型有轻微影响——但除TLR4外的其他TLRs在严重RSV相关疾病的遗传学中并不起主要作用。未来的研究应关注先天性免疫反应的其他基因。
