来自海洋软体动物源放线菌西班牙糖丝菌An 113的新型蒽环类抗生素和抗菌双酮哌嗪。
New angucyclines and antimicrobial diketopiperazines from the marine mollusk-derived actinomycete Saccharothrix espanaensis An 113.
作者信息
Kalinovskaya Nataliya I, Kalinovsky Anatoly I, Romanenko Lyudmila A, Dmitrenok Pavel S, Kuznetsova Tatyana A
机构信息
Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russian Federation.
出版信息
Nat Prod Commun. 2010 Apr;5(4):597-602.
Two new angucyclines, saccharothrixmicines A (2) and B (3), together with three known diketopiperazines 4-6 were isolated from the actinomycete Saccharothrix espanaensis An 113 associated with the marine mollusk Anadara broughtoni. Their structures were determined by HRESI-MS and 1D and 2D NMR. Compounds 2 and 3 differ in aglycone and glycosidic bond type. 2 is an alpha-L-6-deoxyaltrose-phenylglycoside of a benz[a]anthraquinone aglycone, while 3 is an O-glycoside of the same sugar linked to C-7 of the known angucyclinone (1). A saccharothrixmicine-containing fraction exhibited activity towards Candida albicans and Xanthomonas sp. pv. badrii whereas the diketopiperazines showed antibiotic activities against Vibrio alginolyticus and Vibrio parahaemolyticus.
从与海洋软体动物泥蚶相关的放线菌西班牙糖丝菌An 113中分离出两种新的蒽环类抗生素，即糖丝菌素A（2）和B（3），以及三种已知的二酮哌嗪4 - 6。它们的结构通过高分辨电喷雾电离质谱（HRESI-MS）以及一维和二维核磁共振（1D和2D NMR）确定。化合物2和3在苷元和糖苷键类型上有所不同。2是苯并[a]蒽醌苷元的α-L-6-脱氧阿洛糖苯糖苷，而3是与已知蒽环酮（1）的C-7相连的相同糖的O-糖苷。含有糖丝菌素的馏分对白色念珠菌和黄单胞菌属丁香假单胞菌表现出活性，而二酮哌嗪对溶藻弧菌和副溶血性弧菌显示出抗生素活性。
Zotero 插件