优雅狗牙花叶子中的β-咔啉类化合物A-C

Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.

作者信息

Mansoor Tayyab A, Ramalhete Cátia, Molnár Joseph, Mulhovo Silva, Ferreira Maria José U

机构信息

i.Med-UL, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.

出版信息

J Nat Prod. 2009 Jun;72(6):1147-50. doi: 10.1021/np9001477.

DOI:10.1021/np9001477

PMID:19473031

Abstract

Three novel beta-carboline indole alkaloids (1-3) have been isolated from a MeOH extract of the leaves of Tabernaemontana elegans. The structures were established by means of spectroscopic techniques including 2D NMR experiments. Compounds 1 and 2 contain a two-carbon unit, attached to a structurally related beta-carboline skeleton, as part of an additional six-membered ring in 1 and a seven-membered ring in 2. To the best of our knowledge, this is the first report of beta-carboline indole alkaloids from the genus Tabernaemontana. Compounds 1-3 were evaluated for their ability to modulate multidrug resistance in mouse lymphoma cell lines. Compounds 1 and 3 exhibited a weak activity.

摘要

从秀丽狗牙花（Tabernaemontana elegans）叶片的甲醇提取物中分离出了三种新型β-咔啉吲哚生物碱（1-3）。通过包括二维核磁共振实验在内的光谱技术确定了其结构。化合物1和2含有一个与结构相关的β-咔啉骨架相连的二碳单元，在化合物1中作为一个额外六元环的一部分，在化合物2中作为一个七元环的一部分。据我们所知，这是首次从狗牙花属植物中报道β-咔啉吲哚生物碱。对化合物1-3调节小鼠淋巴瘤细胞系多药耐药性的能力进行了评估。化合物1和3表现出较弱的活性。