Cockerell G L, Krakowka S, Hoover E A, Olsen R G, Yohn D S
J Natl Cancer Inst. 1976 Oct;57(4):907-13. doi: 10.1093/jnci/57.4.907.
Membrane markers of feline T- and B-lymphocytes were identified for further investigation of leukemogenesis in the cat. Feline T-cells formed spontaneous erythrocyte rosettes with guinea pig (GPE) and rat erythrocytes (RE). The receptors for GPE and RE were separate entities and expressed independently on lymphoid cell membranes. The RE receptor appeared to be present only on more mature or differentiated T-cells, whereas the GPE receptor reacted with a broader population that included less differentiated T-cells. Feline B-cells bore a complement receptor that was detected by adherence of SE coated with antibody and complement. Malignant lymphoblasts obtained from thoracic fluid of cats with feline leukemia virus (FeLV)-induced thymic lymphosarcomas, as well as FL-74 cells (a FeLV-transformed feline lymphoblastoid cell line) expressed T-cell markers. These results provided definitive evidence for markers of feline T- and B-cells and identified an experimentally induced T-cell lymphosarcoma.
为了进一步研究猫的白血病发生过程，对猫的T淋巴细胞和B淋巴细胞的膜标记物进行了鉴定。猫的T细胞能与豚鼠红细胞（GPE）和大鼠红细胞（RE）形成自发性红细胞玫瑰花结。GPE和RE的受体是独立的实体，在淋巴细胞膜上独立表达。RE受体似乎仅存在于更成熟或分化的T细胞上，而GPE受体能与包括分化程度较低的T细胞在内的更广泛群体发生反应。猫的B细胞带有一种补体受体，可通过包被有抗体和补体的SE的黏附来检测。从感染猫白血病病毒（FeLV）的胸腺淋巴肉瘤猫的胸水中获得的恶性淋巴母细胞，以及FL - 74细胞（一种FeLV转化的猫淋巴母细胞系）均表达T细胞标记物。这些结果为猫T细胞和B细胞的标记物提供了确凿证据，并鉴定出一种实验诱导的T细胞淋巴肉瘤。
