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肝细胞癌与泛素-蛋白酶体系统

Hepatocellular carcinoma and the ubiquitin-proteasome system.

作者信息

Dawson Simon P

机构信息

School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK.

出版信息

Biochim Biophys Acta. 2008 Dec;1782(12):775-84. doi: 10.1016/j.bbadis.2008.08.003. Epub 2008 Aug 20.

DOI:10.1016/j.bbadis.2008.08.003
PMID:18778769
Abstract

Hepatocellular carcinoma is one of the largest causes of cancer-related deaths worldwide for which there are very limited treatment options that are currently effective. The ubiquitin-proteasome system has rapidly become acknowledged as both critical for normal cellular function and a frequent target of de-regulation leading to disease. This review appraises the evidence linking the ubiquitin-proteasome system with this devastatingly intractable cancer and asks whether it may prove to be fertile ground for the development of novel therapeutic interventions against hepatocellular carcinoma.

摘要

肝细胞癌是全球癌症相关死亡的主要原因之一，目前有效的治疗选择非常有限。泛素-蛋白酶体系统已迅速被公认为对正常细胞功能至关重要，且是导致疾病的失调常见靶点。本综述评估了将泛素-蛋白酶体系统与这种极具难治性的癌症联系起来的证据，并探讨它是否可能成为开发针对肝细胞癌的新型治疗干预措施的沃土。

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