三种糖醇对苯扎氯铵对白色念珠菌杀菌作用的增强效果。
The enhancement effect of three sugar alcohols on the fungicidal effect of benzethonium chloride toward Candida albicans.
作者信息
Ichikawa T, Yano Y, Fujita Y, Kashiwabara T, Nagao K
机构信息
Department of Oral & Maxillofacial Prosthodontics and Implantology, The University of Tokushima, Institute of Health Biosciences, 3-18-15 Kuramoto, Tokushima 770-8504, Japan.
出版信息
J Dent. 2008 Nov;36(11):965-8. doi: 10.1016/j.jdent.2008.07.013. Epub 2008 Sep 7.
OBJECTIVE
The purpose of this study was to evaluate if the sugar alcohols erythritol, xylitol and sorbitol enhance the fungicidal effect of benzethonium chloride (BTC) toward in vitro candidal biofilms.
METHODS
An in vitroCandida albicans biofilm was formed on a plastic coverslip coated with type I collagen. The enhancement of the fungicidal effect was evaluated using microbial assay after treating the biofilm with the test solutions (sugar alcohols: erythritol, xylitol, and sorbitol, each containing BTC solution).
RESULTS
No fungicidal effect was observed with sugar alcohols without BTC. The fungicidal effect of erythritol-containing BTC increased with the erythritol concentration. Further, the level of enhancement of erythritol was the highest in three sugar alcohols.
CONCLUSION
Sugar alcohols, especially erythritol, enhanced the fungicidal effect of BTC toward in vitro candidal biofilms.
目的
本研究旨在评估糖醇类赤藓糖醇、木糖醇和山梨醇是否能增强苯扎氯铵（BTC）对体外念珠菌生物膜的杀菌效果。
方法
在涂有I型胶原蛋白的塑料盖玻片上形成白色念珠菌体外生物膜。在用测试溶液（糖醇类：赤藓糖醇、木糖醇和山梨醇，均含有BTC溶液）处理生物膜后，通过微生物测定法评估杀菌效果的增强情况。
结果
不含BTC的糖醇类未观察到杀菌效果。含赤藓糖醇的BTC的杀菌效果随赤藓糖醇浓度的增加而增强。此外，赤藓糖醇的增强水平在三种糖醇中最高。
结论
糖醇类，尤其是赤藓糖醇，增强了BTC对体外念珠菌生物膜的杀菌效果。
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